Elevated survivin levels in patients with acne vulgaris

Saraç, Gülhan Aksoy; Kader, Saadet; Akdağ, Turan

doi:10.1111/jocd.14742

Cited by 3 publications

(1 citation statement)

References 25 publications

(45 reference statements)

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“…In recent research by Kader and Akda [32] , acne sufferers exhibited serum survivin levels that were significantly greater (153.4 pg/ml) than the control group (104.2 pg/ml). Also, there was a substantial association between the SCAR-S score and survivin levels as well as a positive relationship between survivin and the severity of the acne.…”

Section: Discussionmentioning

confidence: 88%

Survivin Gene Polymorphism in Association with Plasma Survivin Level as Potential Risk Factors for Acne Severity and Post-Acne Scaring

State¹,

El-Sohafy²,

Salam³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: Acne vulgaris is the most common cutaneous ailment in the world, affecting up to 80% of teenagers and up to 50% of adults. It is a chronic inflammatory disease of the pilosebaceous unit. The development of acne lesions is heavily influenced by keratinocyte proliferative and inflammatory states, which have been observed to elevate survivin levels.Objective: This study was conducted to assess survivin gene polymorphism and its plasma level in patients with active acne vulgaris and patients with post acne scars with varying severity. Patients and methods:The study included 60 acne patients divided into two groups: 30 patients with active acne lesions and 30 patients with post acne scars; in addition to 30 healthy volunteers who were served as control group selected from Outpatient Clinic,

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Section: Discussionmentioning

confidence: 88%

Survivin Gene Polymorphism in Association with Plasma Survivin Level as Potential Risk Factors for Acne Severity and Post-Acne Scaring

State¹,

El-Sohafy²,

Salam³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Serum survivin in acne versus post-acne scarring and the possible effect of isotretinoin therapy on its level

Hussein¹,

Tawfik²,

Abd-Rabboh³

et al. 2023

Acta Dermatovenerologica Alpina Pannonica Et Adriatica

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Acne Transcriptomics: Fundamentals of Acne Pathogenesis and Isotretinoin Treatment

Melnik

2023

Cells

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This review on acne transcriptomics allows for deeper insights into the pathogenesis of acne and isotretinoin’s mode of action. Puberty-induced insulin-like growth factor 1 (IGF-1), insulin and androgen signaling activate the kinase AKT and mechanistic target of rapamycin complex 1 (mTORC1). A Western diet (hyperglycemic carbohydrates and milk/dairy products) also co-stimulates AKT/mTORC1 signaling. The AKT-mediated phosphorylation of nuclear FoxO1 and FoxO3 results in their extrusion into the cytoplasm, a critical switch which enhances the transactivation of lipogenic and proinflammatory transcription factors, including androgen receptor (AR), sterol regulatory element-binding transcription factor 1 (SREBF1), peroxisome proliferator-activated receptor γ (PPARγ) and signal transducer and activator of transcription 3 (STAT3), but reduces the FoxO1-dependent expression of GATA binding protein 6 (GATA6), the key transcription factor for infundibular keratinocyte homeostasis. The AKT-mediated phosphorylation of the p53-binding protein MDM2 promotes the degradation of p53. In contrast, isotretinoin enhances the expression of p53, FoxO1 and FoxO3 in the sebaceous glands of acne patients. The overexpression of these proapoptotic transcription factors explains isotretinoin’s desirable sebum-suppressive effect via the induction of sebocyte apoptosis and the depletion of BLIMP1(+) sebocyte progenitor cells; it also explains its adverse effects, including teratogenicity (neural crest cell apoptosis), a reduced ovarian reserve (granulosa cell apoptosis), the risk of depression (the apoptosis of hypothalamic neurons), VLDL hyperlipidemia, intracranial hypertension and dry skin.

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Elevated survivin levels in patients with acne vulgaris

Cited by 3 publications

References 25 publications

Survivin Gene Polymorphism in Association with Plasma Survivin Level as Potential Risk Factors for Acne Severity and Post-Acne Scaring

Survivin Gene Polymorphism in Association with Plasma Survivin Level as Potential Risk Factors for Acne Severity and Post-Acne Scaring

Serum survivin in acne versus post-acne scarring and the possible effect of isotretinoin therapy on its level

Acne Transcriptomics: Fundamentals of Acne Pathogenesis and Isotretinoin Treatment

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