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Sarcoidosis is a chronic inflammatory disease with a complex pathogenesis and unknown etiology characterized by noncaseating granulomas that invade the lungs, eyes, liver and other organs. Insertion (I)/deletion (D) polymorphism in the gene encoding the angiotensin-converting enzyme (ACE) has been studied to examine the genetic predisposition to sarcoidosis in different populations, but the results have been inconsistent and inconclusive. This study aimed to determine the frequencies of the genotypes and alleles of I/D polymorphism in the ACE gene in Turkish patients as a distinct ethnic group and to investigate whether such polymorphism is associated with predisposition to sarcoidosis. Genomic DNA samples obtained from 154 individuals (70 patients with sarcoidosis and 84 healthy controls) were used in the study. The DNA was amplified using polymerase chain reactions using allele-specific primers. The amplified products were analyzed by 2 % agarose gel electrophoresis followed by UV transillumination. The allele frequencies and genotype distribution of the groups were analyzed using the Chi square test. There were no significant differences between the controls and sarcoidosis cases with respect to genotype distribution (v 2 = 4.202, p = 0.122) and allele frequencies (v 2 = 1.358, p = 0.244). Our results suggest that I/D polymorphism in the ACE gene does not cause a genetic predisposition to sarcoidosis in Turkish patients.

Cyprus Journal of Medical Sciences (Cyprus J Med Sci) is the peer-reviewed, open access, international publication organ of Cyprus Turkish Medical Association. The journal is printed three times a year in April, August and December. The publication language of the journal is English. Cyprus Journal of Medical Sciences aims to publish manuscripts at the highest clinical and scientific level on all fields of medicine. The journal publishes original papers, review articles, case reports and letters. Cyprus Journal of Medical Sciences is indexed in Web of Science-Emerging Sources Citation Index and EBSCO.

This study demonstrated that, occupations exposed to high-density quartz dust such as sandblasting workers, are at a much higher risk of developing PMF than other professions. No significant relationship was found between large opacity size and smoking status, concomitant tuberculosis, or duration of dust exposure.

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Enfeksiyon hastalıkları içinde solunum yolu ile bulaşan hastalıklar kısa sürede pek çok insana bulaşabilme özelliği nedeniyle toplum sağlığı açısından önemli bir yer oluşturmaktadır. Tarihsel süreçte insanoğlu zorlu pek çok pandemi ile mücadele etmiş ve ciddi kayıplar vermiştir. Günümüzde yine solunum yoluyla bulaşan COVID-19 pandemisiyle tüm Dünya mücadele etmektedir. Bu süreçte tüm toplumun olduğu kadar sağlık çalışanlarının da bulaşıcı hastalıklardan korunmaları adına kişisel koruyucu ekipman ve özellikle maske kullanımı enfeksiyon zincirini kırmak için gerekli bir uygulamadır. Sağlık çalışanlarının pandemi döneminde koruyucu ekipmanlar içerisinde özellikle maske kullanım ihtiyacı da artmaktadır. Özellikle hastaların tanı, tedavi ve girişimsel işlemleri gibi yakın temasın olduğu sırada yüksek koruyuculuğu olan filtreli yüz maskelerinin kullanılması gerekmektedir. Ülkelerin sağlık politikalarında almış olduğu kararlar doğrultusunda sağlık çalışanlarına uygun ve yeterli sayıda koruyucu ekipman sağlayabilmeleri muhtemeldir. Ancak bazı durumlarda filtreli yüz maskelerinin uzun süreli veya yeniden kullanımı gerekebilir. Yeniden kullanım belirli proserdürlerde, belli kurallar çerçevesince yapıldığı takdirde, filtreli yüz maskelerinin yeterli sayıda tedarik sürecinde sorun yaşandığında bir çözüm yolu olarak düşünülebilir.

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Introduction In this study, we aimed to investigate the relationship between postoperative mortality, morbidity, hospital stay and development of postoperative complications with the glycosylated hemoglobin (HbA1c) level and low left ventricular ejection fraction (LVEF) in diabetic and non-diabetic patients who underwent elective coronary artery bypass (CABG) surgery. Methods The medical records of patients who underwent CABG at our clinic between January 2015 and December 2019 were retrospectively analyzed. All patients were divided into two groups according to their diabetes mellitus (DM) diagnosis. Diabetic patients were also divided into two groups according to their HbA1c levels. The HbA1c threshold value was 7%. All patients were divided into two groups in terms of LVEF. The LVEF threshold value was 40%. Results We analyzed 393 patients, of which 304 (77.4%) were male and 177 (45.04%) patients were diabetic. For lower LVEF and HbA1c values, we found no relationship between postoperative mortality, prolonged intensive care unit (ICU) stay and development of postoperative complications. Deep surgical site infection (DSSI) was found to be more common in diabetic patients who had a higher HbA1c value. Length of hospital stay was longer in diabetic patients with HbA1c levels <7%. Conclusion No statistically significant relationship was found between LVEF and HbA1c levels and postoperative mortality, prolonged ICU stay and postoperative complications.