Informed consent is a term based on the idea that every individual has the right to know every medical intervention that is going to be performed on their own body and to learn the issues that she/he may encounter in case of refusal of intervention, and it also defines the protection of personal rights under the guarantee of law. Material and Methods: The website of Turkish Surgical Association and 25 different websites of surgical associations were evaluated according to general surgery association guide, which was published by the Turkish Surgical Association in 2011. Results: Four websites of those surveyed include informed consent sections and these were evaluated. A total of 44 informed consent forms were included in this study. Of these, 29 were in Turk Colon and Rectum Surgery Association, 8 were in Turkish Surgery Association, 5 were in Turk Hepatopancreaticobilier Surgery Association, and 4 were in Endocrine Surgery Association. These informed consent forms were evaluated with regard to the aforementioned criteria. The results and also the distribution according to the associations were summarized. A common feature of the informed consent forms was that all of them included the risks of the intervention/operation and complications to be carried out. On the contrary, none of them included approximate time of surgery, information about surgeons, issues that patients should care about before surgery, the section that permits the use of data for scientific purpose, and the time of signing the informed consent form. Conclusion: We believe that in this context the regulation of informed consent by sub-specialization associations under the flag of Turkish Surgical Association is a very important matter and will standardize informed consents; websites of the associations will be easier to access, and this will be as beneficial for physicians as the patients and also will protect the physicians in probable trials.
Ki-67 hücre siklusunda G0 fazı dışında eksprese edilen nükleer bir proteindir. Prolifere olan hücreleri gösteren belirteç olarak kullanılmaktadır. Meme kanseri tanılı hastalarda Ki-67 proliferasyon indeksinin kötü klinik sonuçlarla ilişkili olduğu gösterilmiştir. Bu çalışmada östrojen reseptörü ve progesteron reseptörü pozitif, HER-2 negatif, aksiller lenf nodu tutulumu bulunmayan meme kanseri tanılı hastalarda Ki-67 proliferasyon indeksinin prognostik öneminin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: 2006-2014 yılları arasında tanı konulan ve tıbbi onkoloji kliniğinde izlemi bulunan opere meme kanseri tanılı hastalar çalışmaya dahil edildi. İmmunohistokimyasal olarak nükleer Ki-67 proliferasyon indeksi değerlendirildi. Diğer klinikopatolojik prognostik faktörlerle ilişkisi değerlendirildi. Bulgular: 162 hasta çalışmaya dahil edildi. Medyan 85 (9-132) aylık izlemde 2 (%1.2) hastada lokal nüks, 7 (%4.3) hastada uzak metastaz saptandı. Sekiz (%4.9) hasta vefat etti. Ki-67 proliferasyon indeksine göre Roc curve analizinde elde edilen %20 değerine göre hastalar iki gruba ayırıldı. Ki-67 proliferasyon indeksi %20'nin altında ve üzerinde olan gruplarda 7 yıllık genel sağkalımlar sırasıyla %97.1 ve %90.9 olarak hesaplandı (p0.042). Ki-67 proliferasyon indeksinin tümör histolojik derecesi, patolojik tümör boyutu ile pozitif korelasyon, hormon reseptörleri ile negatif korelasyon gösterdiği saptandı. Sonuç: Proliferasyon meme kanserinde prognoz ve tedavi yanıtını predikte etmek için kullanılan önemli bir göstergedir. Ki-67 proliferasyon indeksi için standart eşik değeri bulunmaması, değerlendirme ve skorlama metodolojisinde standart olmamasına rağmen diğer klinikopatolojik prognostik göstergelerle birlikte prognoz belirlenmesinde kullanılmaktadır
Stoma surgery is a more morbid procedure in colorectal surgery, compared to other procedures. In the predictive scoring systems, the mortality associated with colorectal surgery is evaluated by a combination of physical and operative parameters; however, stoma surgery is not addressed individually among the operative parameters. This study aims to determine whether the surgeons, who decide in the formation of stomata, own an acquired ability to predict mortality. Four hundred thirteen patients who underwent ileostomy and colostomy formation were included in the study. All patients were evaluated in two time periods: the first 30 days after surgery (short) and in the long term. As a result, short-and long-term mortality rates were observed to be high with statistical significance. When the patients with various etiologies but with the same surgery conditions, in the short term, no statistical differences were observed in the mortality rates statistically; however, by the multivariate analysis, the mortality rates were found to be 1809 times more in patients with benign etiologies. High mortality rates with statistical significance were observed in the long term in patients with malignancies. In conclusion, the decision on stoma requirement is a predictor of mortality both in the early period and in the long term. Stoma must be included in the future colorectal surgery mortality prediction scoring systems, individually and aside from the surgical intervention, as a factor increasing the potential for mortality.
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