Östrojen-Progesteron Reseptörü Pozitif ve Aksiller Lenf Nodu Negatif Meme Kanseri Tanılı Hastalarda Ki-67 Proliferasyon İndeksi

Kucukzeybek, Betul Bolat; Taşkaynatan, Halil; Sarı, Ayşegül; Yiğit, Seyran; Balli, Gülden; Etıt, Demet; Yazıcı, Ayşe Canan; Atahan, Kemal; Büyüktalanci, Dilara Özyiğit; Alacacıoğlu, Ahmet; Küçükzeybek, Yüksel

doi:10.18521/ktd.430081

Cited by 2 publications

(2 citation statements)

References 34 publications

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“…Small, low-grade tumors with low rates of axillary involvement are more likely to belong to the ER + PR ± HER2-group. 29 Bolat Küçükzeybek et al reported a positive correlation of KI-67 proliferation index with histological grade and tumor size, as well as a poor effect at 7-year OS 30 .…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of KI-67 proliferation index in luminal breast cancers

Dokcu,

Ali-Óaparlar,

ÓetindaÓ

et al. 2024

CIRUE

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Objective: This study aimed to examine the prognostic significance of the KI-67 proliferation index, especially in breast cancer (BC) patients without HER-2 expression and no nodal involvement. Material and methods: The database of hormone-receptor-positive patients who underwent surgery for BC in our Surgical Oncology Clinic between 2008 and 2020 was retrospectively reviewed and recorded. Patients were categorized based on their KI-67 level, considering the cutoff value of 20%. Results: Our study revealed that tumors with high KI-67 levels were more likely to have a more advanced histological grade (p = 0.00) and size (p = 0.038). In the univariant analysis, KI-67 level was effective on overall survival (p = 0.044) and disease-free survival (p = 0.048). However, we found that there was no independent prognostic factor in the multivariant analysis. Conclusion: Although the Ki-67 proliferation index does not yet have an agreed threshold value and scoring methodology, it can also be used to determine prognosis and evaluate treatment response in some patients.

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Section: Discussionmentioning

confidence: 99%

Prognostic value of KI-67 proliferation index in luminal breast cancers

Dokcu,

Ali-Óaparlar,

ÓetindaÓ

et al. 2024

CIRUE

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“…Tumor cells are classified as hormone receptorpositive or negative, depending on their receptor expression profile. Knowing the expression status of the hormone receptor is an essential factor in selecting the treatment strategy to be applied (38). In the follow-up of this section, basic information about the ER protein, which is known to be closely associated with breast cancer, and signaling pathways controlled by the ER will be shared.…”

Section: Breast Cancer Associated Receptorsmentioning

confidence: 99%

Breast cancer and the molecular mechanism of estrogen signaling

Erzurumlu

DOĞAN

2023

Interdisciplinary Medical Journal

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Cancer is a complex pathology that occurs due to the uncontrolled proliferation and growth of cells in any organ or tissue of the body. Breast cancer is the most frequently diagnosed cancer among women worldwide and is the second leading cause of cancer-related deaths. Breast cancer is a pathology that exhibits heterogeneity in which genetic and environmental risk factors play a role. Although many treatment approaches have been developed for breast cancer today, the frequency of the number of patients diagnosed with breast cancer and lost their lives due to this reason is increasing in the world. The most significant limitation to the success of the treatment approaches developing drug resistance in breast cancer cells, and the disease relapses after a certain period and exhibits a more aggressive profile. Therefore, understanding the molecular biology of breast cancer is essential for developing potent therapeutic approaches. It is known that the development of breast cancer is related to changes in direct and indirect signaling mechanisms mediated by estrogen and estrogen receptor. These signaling mechanisms exhibit highly complex interaction patterns. This review summarizes the pathology of breast cancer, estrogenic compounds, estrogen receptors, genomic and non-genomic molecular signaling mechanisms mediated by estrogen and estrogen receptor.

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Östrojen-Progesteron Reseptörü Pozitif ve Aksiller Lenf Nodu Negatif Meme Kanseri Tanılı Hastalarda Ki-67 Proliferasyon İndeksi

Cited by 2 publications

References 34 publications

Prognostic value of KI-67 proliferation index in luminal breast cancers

Prognostic value of KI-67 proliferation index in luminal breast cancers

Breast cancer and the molecular mechanism of estrogen signaling

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