A method using supercritical CO(2) to obtain biocompatible 2-oxazoline-based oligomers quaternized with different amines is described. The synthesized oligo(2-oxazoline)s display partial carbamic-acid insertion at one end. The syntheses of quaternary oligo(2-bisoxazoline)s and linear oligoethylenimine hydrochlorides are reported. Oligo(2-methyl-2-oxazoline) and oligo(2-bisoxazoline) quaternized with N,N-dimethyldodecylamine are the most efficient biocidal agents showing fast killing rates against Staphylococcus aureus and Escherichia coli. Linear oligoethylenimine hydrochloride shows the lowest MIC values but higher killing times against both bacteria. Based on the antimicrobial activity studies, a cooperative action of carbamic acid with the ammonium end group is proposed.
Back Cover: The cover image shows that 2‐oxazoline‐based oligomers quaternized with different amines can be successfully synthesized using a supercritical‐fluid‐assisted strategy. They exhibit high antimicrobial activity against S. aureus and E. coli while being biocompatible. Further details can be found in the article by V. G. Correia, V. D. B. Bonifácio, V. P. Raje, T. Casimiro, G. Moutinho, C. Lobato da Silva, M. G. Pinho, and A. Aguiar‐Ricardo* .
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.