Macromol. Biosci. 8/2011

Correia, Vanessa G.; Bonifácio, Vasco D. B.; Raje, Vivek P.; Casimiro, Teresa; Moutinho, Guilhermina; Silva, Cláudia Lobato da; Pinho, Mariana G.; Aguiar‐Ricardo, Ana

doi:10.1002/mabi.201190023

Cited by 7 publications

(8 citation statements)

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“…Moreover the only non‐pharmaceutical grade PEG showed the highest cytotoxicity, possibly due to a higher amount of impurities. The absence of cytotoxic effects in cell proliferation assays for both PMOXA and PEtOXA was corroborated by several independent studies 120, 131, 132…”

Section: Discussionsupporting

confidence: 69%

“…Finally, PMOXA‐QAC macromonomers were successfully used to fabricate antimicrobial hydrogels 119, 116. Corroborating these findings, Correia et al120 demonstrated the synthesis of dodecylammonium‐terminated oligo(2‐methyl‐2‐oxazoline) and oligo(2‐ethyl‐2‐oxazoline) in supercritical carbon dioxide. While the introduction of a quaternary ammonium terminal group increased the cytotoxicity of the oligomers as compared to hydroxyl‐terminated oligomers, the high antibacterial activity combined with a fast killing rate provided a promising therapeutic window.…”

Section: Functional Antifouling Coatingsmentioning

confidence: 91%

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Polyoxazolines for Nonfouling Surface Coatings — A Direct Comparison to the Gold Standard PEG

Konradi¹,

Acikgöz

Textor

2012

Macromol. Rapid Commun.

225

237

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The prevention of surface fouling is becoming increasingly important for the development of anti-infective medical implants, biosensors with improved signal-to-noise ratios, and low-fouling membranes to name a few examples. We review a direct comparison of poly(ethylene glycol), the gold standard polymer to impart surfaces with nonfouling properties, to an alternative polymer, poly(2-methyl-2-oxazoline) (PMOXA), and show that both polymers are equally excellent in rendering surfaces nonfouling while PMOXA coatings are more stable in oxidative environments. We discuss prerequisites for the fabrication of nonfouling surface coatings and implications for the polymer choice according to application requirements.

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Section: Discussionsupporting

confidence: 69%

Section: Functional Antifouling Coatingsmentioning

confidence: 91%

Polyoxazolines for Nonfouling Surface Coatings — A Direct Comparison to the Gold Standard PEG

Konradi¹,

Acikgöz

Textor

2012

Macromol. Rapid Commun.

225

237

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“…Materials and Methods : The PURE G4 dendrimer was synthesized as previously reported . PURE G4 OMeOx and PURE G4 OEtOx were obtained by endcapping of PURE G4 with living oligo(2‐oxazoline)s, which were previously synthesized by supercritical CO 2 ‐assisted cationic ring opening polymerization, using a high‐pressure apparatus . CHT (viscosity 5–20 mPa s, 0.5% in 0.5% acetic acid at 20 °C, degree of deacetylation 75.0%–85.0%) was purchased from Tokyo Chemical Industry.…”

Section: Methodsmentioning

confidence: 99%

Nano-in-Micro POxylated Polyurea Dendrimers and Chitosan Dry Powder Formulations for Pulmonary Delivery

Restani

Silva

Pires

et al. 2016

Part. Part. Syst. Charact.

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Pulmonary administration offers excellent advantages over conventional drug delivery routes, including increasing therapeutics bioavailability, and avoiding long‐term safety issues. Formulations of nano‐in‐micro dry powders for lung delivery are engineered using (S)‐ibuprofen as a model drug. These biodegradable formulations comprise nanoparticles of drug‐loaded POxylated polyurea dendrimers coated with chitosan using supercritical‐fluid‐assisted spray drying. The formulations are characterized in terms of morphology, particle‐size distribution, in vitro aerodynamic particle pulmonary distribution, and glutathione‐S‐transferase assay. It is demonstrated that ibuprofen‐loaded nanoparticles can be successfully incorporated into microspheres with adequate aerodynamic properties, mass median aerodynamic diameter (1.86–3.83 μm), and fine particle fraction (28%–45%), for deposition into the deep lung. The (S)‐ibuprofen dry powder formulations show enhanced solubility, high swelling behavior and a sustained drug release at physiologic pH. Also, POxylated polyureas decrease the (S)‐ibuprofen toxic effect on cancer cellular growth. The 3‐(4,5‐dimethylthiazol‐2‐yl)‐5‐(3‐carboxymethoxyphenyl)‐2‐(4‐sulfophenyl)‐2H‐tetrazolium (MTS) assays show no significant cytotoxicity on the metabolic activity of human lung adenocarcinoma ephithelial (A549) cell line for the lowest concentration (1 × 10−3 m), even for longer periods of contact with the cells (up to 120 h), and in the normal human dermal fibroblasts cell line the toxic effect is also reduced.

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“…One attractive category of polymers is PEI, one of the polymers with the highest amine content. Linear PEI containing terminal primary amines and secondary amines in the backbone shows potent antimicrobial capability, with MIC being able to be reduced to 31 µg/mL for E. coli and 8 µg/mL for S. aureus , respectively, and lower than the precursor, oligo(2‐oxazoline)s . In comparison, branched PEI, containing primary, secondary, and tertiary amines, showed less antimicrobial activity in vitro when incubation time with bacteria was 24 h; but no significant difference when incubation time was 48 h .…”

Section: Introductionmentioning

confidence: 96%

Developments in antimicrobial polymers

Ren

Cheng

Wang

et al. 2016

J. Polym. Sci. Part A: Polym. Chem.

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Effective antimicrobial polymers have been attracting more interests because of the low propensity to cause drug‐resistant microorganisms. The recent progresses in antimicrobial polymers are updated according to the action approaches, that is, antimicrobial polymers with free mobility or fixed on surfaces, respectively. Free antimicrobial polymers kill pathogens majorly via electrostatic interaction followed by disruption of the cell membranes; strong antimicrobial activity of primary/secondary amines, new chemical units, and peptides without facial amphiphilicity are highlighted; and the dependences on amphiphilicity, topology, and self‐assembly profiles are summarized. Antimicrobial polymers fixed on surfaces kill pathogens via interaction with the cell membranes of pathogens via electrostatic or hydrophobic interaction; approaches to antimicrobial surfaces based on covalently grafting, anchoring, and bulk‐mixing of polymers are summarized; and new designs of sustainable antimicrobial surfaces and hydrogels are highlighted. Deep biology understanding and development strategies of materials are suggested for the future. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 632–639

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Macromol. Biosci. 8/2011

Cited by 7 publications

References 0 publications

Polyoxazolines for Nonfouling Surface Coatings — A Direct Comparison to the Gold Standard PEG

Polyoxazolines for Nonfouling Surface Coatings — A Direct Comparison to the Gold Standard PEG

Nano-in-Micro POxylated Polyurea Dendrimers and Chitosan Dry Powder Formulations for Pulmonary Delivery

Developments in antimicrobial polymers

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