Cardiovascular disease is still one of the leading causes of death in the world, and heart transplantation is the current major treatment for end-stage cardiovascular diseases. However, because of the shortage of heart donors, new sources of cardiac regenerative medicine are greatly needed. The prominent development of tissue engineering using bioactive materials has creatively laid a direct promising foundation. Whereas, how to precisely pattern a cardiac structure with complete biological function still requires technological breakthroughs. Recently, the emerging three-dimensional (3D) bioprinting technology for tissue engineering has shown great advantages in generating micro-scale cardiac tissues, which has established its impressive potential as a novel foundation for cardiovascular regeneration. Whether 3D bioprinted hearts can replace traditional heart transplantation as a novel strategy for treating cardiovascular diseases in the future is a frontier issue. In this review article, we emphasize the current knowledge and future perspectives regarding available bioinks, bioprinting strategies and the latest outcome progress in cardiac 3D bioprinting to move this promising medical approach towards potential clinical implementation.

Sepsis is a systemic inflammatory response syndrome caused by infection. With high morbidity and mortality of this disease, there is a need to find early effective diagnosis and assessment methods to improve the prognosis of patients. Heparin-binding protein (HBP) is a granular protein derived from polynuclear neutrophils. The biosynthetic HBP in neutrophils is rapidly released under the stimulation of bacteria, resulting in increased vascular permeability and edema. It is reasonable to speculate that the HBP in plasma may serve as a novel diagnostic marker for sepsis, bacterial skin infection, acute bacterial meningitis, leptospirosis, protozoan parasites, and even some noncommunicable diseases. It implies that in the detection and diagnosis of sepsis, it will be possible to make relevant diagnosis through this new indicator in the future. In this review, we summarize the typical biological function of HBP and its latest research progress to provide theoretical basis for clinical prediction and diagnosis of sepsis.

In recent years, China has felt the urgent need to address the ecological issues caused by its rapid economic growth. In doing so, one challenge it faces is how to address the interests of the various stakeholders involved. To this end, the Government of China at various levels has been exploring and implementing policies, measures and projects that serve as mechanisms or measures of eco-compensation. This article attempts to capture some of the key policies and practices established to date in China. The article concludes by outlining China's possible future priority actions in eco-compensation and key challenges ahead.

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The ecological protection of the watersheds in China is being confronted with a lot of problems such as soil and water erosion, water pollution at present. Therefore watershed eco-compensation is becoming a question of common interest. Based on the analyses of the major problems and their origins in the watershed protection in China, the paper discusses the concerned policies including relative rules and laws, financial policies and water right transaction policies. Simultaneously the paper reviews the practices carried out in China, including the ecological construction project in the western China, the trans-provincial eco-compensation practice and the small watershed eco-compensation practice. According to the present situation of eco-compensation practices and the future policy requirement, this paper finally puts forward four key problems to be solved in the watershed eco-compensation of China in the future.

CD8+CD28− T suppressor cells (Ts) have been recently documented to play an important role in alloimmunity. Therefore, understanding and optimizing the conditions under which these cells are generated and/or expanded would greatly facilitate further research and potential clinical use. In this study, we describe rapid expansion of human allospecific CD8+CD28− Ts cells through coculture of CD8+ T cells with human leukocyte antigen-mismatched donor antigen-presenting cells plus IL-15 in a relative short period of time in vitro. Interestingly, IL-15 promotes the expansion of CD8+CD28− Ts cells through several parallel mechanisms. The expanded CD8+CD28− Ts cells upregulate expression of CD132, CD25, and programmed cell death protein 1 (PD-1), but downregulate expression of CD122, GZM-B, and perforin, while exhibiting no cytotoxicity. Most importantly, the expanded CD8+CD28− Ts cells vigorously inhibit CD4+ T cells proliferation in a contact-dependent and donor-specific manner both in vitro and in vivo. Interestingly, the co-inhibitory molecules PD-1 and programmed death-ligand 1 play an obligatory role in the mechanisms of CD8+CD28− Ts cells suppression. Taken together, our study report novel methodology for IL-15-induced expansion of human CD8+CD28− Ts cells and possible mechanisms. These findings may facilitate understanding of transplant rejection and promote clinical application of CD8+CD28− Ts cell-based strategies for inducing and monitoring transplant tolerance in the future.

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Introduction Payments for Ecosystem Services (PES) programs have been implemented globally to protect ecosystems while securing the well-being of affected people. Reasonable payment standards are key to successful PES programs. Although some approaches are available for determining payment standards, few studies have applied them for grassland conservation with location indicators and socioeconomic contexts properly considered. Methods Using China’s first pilot Grassland Ecological Compensation Policy (GECP) as an example, we analyzed the effects of payment levels, other natural and socioeconomic factors on herders’ willingness to participate in the GECP in Damao County in Inner Mongolia where grassland degradation is happening at an alarming rate due to overgrazing and cropland expansion. Outcomes Our results show that households with lower herding income, older age, higher education, larger grassland areas, and worse social relationships are more inclined to participate in the GECP. Conservation payment level, as well as natural and socioeconomic contextual factors, significantly affect the response of herdsmen, and a reasonable grassland payment standard with a 95% policy compliance rate should be 8.8 yuan mu −1 . Discussion and Conclusion Our findings can inform governments to develop effective PES programs to balance the need of human well-being improvement and grassland conservation in China and beyond.