Maturation of induced pluripotent stem cell-derived cardiomyocytes and its therapeutic effect on myocardial infarction in mouse

Wu, Pei‐Chun; Sai, Xiyalatu; Li, Zhetao; Ye, Xing; Jin, Li; Liu, Guihuan; Li, Ge; Yang, Pingzhen; Zhao, Mingyi; Zhu, Shuoji; Liu, Nanbo; Zhu, Ping

doi:10.1016/j.bioactmat.2022.05.024

Cited by 9 publications

(7 citation statements)

References 54 publications

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“…79−82 Fatality of heart diseases partially results from the inability or extremely low capacity of CMs to proliferate. 83 BMs that support the attachment, growth, and function of CMs are highly desired for both research and clinical purposes. Typical BMs for CMs include natural polymers (e.g., alginate, collagen, gelatin, chitosan, hyaluronic acid, and extracellular matrix (ECM)), synthetic polymers (e.g., polyethylene glycol, polylactide, polyurethane, poly(N-isopropylacrylamide), polycaprolactone, poly(lactic-co-glycolic acid)), and hybrid BMs.…”

Section: Cardiomyocyte−biomaterials Researchmentioning

confidence: 99%

Transcriptomic Approaches to Cardiomyocyte–Biomaterial Interactions: A Review

Wen,

Yang,

Hong

2024

ACS Biomater. Sci. Eng.

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Section: Cardiomyocyte−biomaterials Researchmentioning

confidence: 99%

Transcriptomic Approaches to Cardiomyocyte–Biomaterial Interactions: A Review

Wen,

Yang,

Hong

2024

ACS Biomater. Sci. Eng.

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“…Induced pluripotent stem cells, mesenchymal stem cells and myocardial progenitor cells have been widely used in stem cell therapy (39). However, directly injected stem cells can't fully differentiate into cardiomyocytes, most of which will die in the process of transplantation and be unable to grow in the specified location (40). In addition, the surviving cells can't integrate well with the host myocardium, so wrapping stem cell-induced cardiomyocytes into the damaged heart in conductive hydrogels is a good strategy to promote cardiomyocyte maturation and help myocardial regeneration (2).…”

Section: Promote Myocardial Regenerationmentioning

confidence: 99%

Application of conductive hydrogels in cardiac tissue engineering

2023

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The fatality rate of myocardial infarction ranks first in cardiovascular disease, which is myocardial necrosis caused by persistent ischemia and hypoxia caused by coronary artery occlusion. Myocardial infarction leads to the irreversible loss of a large number of cardiomyocytes. Exogenous cardiomyocyte supplement is an ideal method for the treatment of myocardial infarction. However, myocardial infarction leads to the loss of electrical conductivity of myocardial tissue at the infarcted site, and it is difficult for exogenous cardiomyocytes to integrate effectively. So, it is necessary to reshape the microenvironment of the infarcted site and restore its electrical conductivity. The construction of heart tissue engineering combined with biomaterials, cells and bioactive molecules is a hot topic in recent years. Conductive hydrogels, as an ideal scaffold material can promote the maturation of cardiomyocytes in vitro, give effective mechanical support to the infarcted site, improve the electrical conductivity of infarcted tissue, help exogenous cardiomyocytes integrate in vivo and restore heart function gradually. In this paper, we review the natural substrate materials used to make conductive hydrogels, the emerging trend of conductive materials and the applications of conductive hydrogels in heart tissue engineering.

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“…To prevent adverse heart remodeling while promoting cardiomyocyte regeneration and blood vessel formation, researchers have developed hydrogels loaded with various cells to treat MI. [156][157][158] Treatment by basal stem cells has proved to be a promising strategy for the treatment of MI. Stem cells have the ability to self-renew and differentiate into various cell types, giving them an important role in repairing and regenerating damaged heart muscle.…”

Section: Cell-loaded Hydrogels For the Treatment Of MImentioning

confidence: 99%

Hydrogels for the Treatment of Myocardial Infarction: Design and Therapeutic Strategies

Liang,

Lv,

et al. 2023

Macromolecular Bioscience

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Cardiovascular diseases (CVDs) have become the leading global burden of diseases in recent years and are the primary cause of human mortality and loss of healthy life expectancy. Myocardial infarction (MI) is the top cause of CVDs‐related deaths, and its incidence is increasing worldwide every year. Recently, hydrogels have garnered great interest from researchers as a promising therapeutic option for cardiac tissue repair after MI. This is due to their excellent properties, including biocompatibility, mechanical properties, injectable properties, anti‐inflammatory properties, antioxidant properties, angiogenic properties, and conductive properties. This review discusses the advantages of hydrogels as a novel treatment for cardiac tissue repair after MI. The design strategies of various hydrogels in MI treatment are then summarized, and the latest research progress in the field is classified. Finally, the future perspectives of this booming field are also discussed at the end of this review.

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Maturation of induced pluripotent stem cell-derived cardiomyocytes and its therapeutic effect on myocardial infarction in mouse

Cited by 9 publications

References 54 publications

Transcriptomic Approaches to Cardiomyocyte–Biomaterial Interactions: A Review

Transcriptomic Approaches to Cardiomyocyte–Biomaterial Interactions: A Review

Application of conductive hydrogels in cardiac tissue engineering

Hydrogels for the Treatment of Myocardial Infarction: Design and Therapeutic Strategies

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