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Myocardial injury is a serious complication of sepsis. The present study aimed to identify potential biomarkers of sepsis-induced myocardial injury. Differentially expressed genes (DEGs) in patients and mice with sepsis-induced myocardial injury were identified via bioinformatic analysis. The identified DEG was tested in elderly patients with sepsis-induced myocardial injury. We identified 19 co-expressed DEGs. The most significant DEG was eotaxin-1/CCL11. We enrolled 25 controls without infections and 28 patients with sepsis-induced myocardial injury. Six of patients died within 30 days. Circulating eotaxin-1/CCL11 levels were significantly higher in patients with sepsis-induced myocardial injury than controls and were higher in nonsurvivors than survivors (both P < 0.01). Eotaxin-1/CCL11 was positively correlated with troponin I (r=0.48, P=0.01), B-type natriuretic peptide (BNP, r=0.44, P=0.02), and white blood cell (WBC) count (r=0.41, P=0.03). For the prediction of 30-day mortality, eotaxin-1/CCL11 had the greatest discriminatory ability (AUC 0.97) compared with troponin I (AUC 0.89), BNP (AUC 0.80), and WBC count (AUC 0.86). Taken together, eotaxin-1/CCL11 was upregulated in sepsis-injured myocardium and circulating eotaxin-1/CCL11 was a biomarker for predicting severity and mortality of elderly patients with sepsis-induced myocardial injury. These results suggest that eotaxin-1/CCL11 may become a useful biomarkers and potential therapeutic target for sepsisinduced myocardial injury.

Effects of some kinds of alumina on physical properties of high-purity andalusite based refractory were studied, and, effects of type and amount of added alumina on phase composition and microstructure of the refractory were investigated by XRD and SEM. The results revealed that the sintering property of the refractory sample without added alumina was better than that of one with added alumina, whereas the effect of a selected sample of added alumina on the sintering property of the high-purity andalusite based refractory was related to the purity and activity of the added alumina sample. The SiO 2 glass phase originated from the decomposed andalusite aggregate cannot wholly react with added alumina to form secondary mullite. Moreover, when the quantity of added alumina amounted to about 15% (mass percent), more extensive secondary mullitization and greater expansion will be observed in the experimental sample.

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