Whether native speakers of non-tonal languages can acquire categorical representations of lexical tones remains controversial. This study investigates the acquisition of lexical tone categories by native English speakers learning Mandarin Chinese as a foreign language by comparing the categorical perception (CP) of lexical tones between three groups of listeners: (1) native English speakers who had taken advanced Mandarin courses in colleges; (2) native English speakers with no knowledge of Mandarin Chinese; and (3) native Mandarin speakers. Two tonal continua derived from natural speech within carrier phrases were created through interpolation within two tonal contrasts (tone 1/tone 4, T1/T4; tone 2/tone 3, T2/T3). Results showed categorical-like perception of tones by native Mandarin speakers. The inexperienced English speakers performed near chance on discrimination tasks and showed significantly broader identification boundaries than the other two groups. The learners of Mandarin showed similar pattern of CP to native Mandarin speakers, but with higher overall discrimination scores. Findings suggest that CP of lexical tone may be available to advanced second language learners.

Brain responses to tactile stimulation have often been studied through the examination of ERPs elicited to touch on the body surface. Here, we examined two factors potentially modulating the amplitude of the somatosensory mismatch negativity (sMMN) and P300 responses elicited by touch to pairs of body parts: (a) the distance between the representation of these body parts in somatosensory cortex, and (b) the physical distances between the stimulated points on the body surface. The sMMN and the P300 response were elicited by tactile stimulation in two oddball protocols. One protocol leveraged a discontinuity in cortical somatotopic organization, and involved stimulation of either the neck or the hand in relation to stimulation of the lip. The other protocol involved stimulation to the third or fifth finger in relation to the second finger. The neck-lip pairing resulted in significantly larger sMMN responses (with shorter latencies) than the hand-lip pairing, whereas the reverse was true for the amplitude of the P300. Mean sMMN amplitude and latency did not differ between finger pairings. However, larger P300 responses were elicited to stimulation of the fifth finger than the third finger. These results suggest that, for certain combinations of body parts, early automatic somatosensory mismatch responses may be influenced by distance between the cortical representations of these body parts, whereas the later P300 response may be more influenced by the distance between stimulated body parts on the body surface. Future investigations can shed more light on this novel suggestion.

This study examines brain responses to boundary effects with respect to Mandarin lexical tone continua for three groups of adult listeners: (1) native English speakers who took advanced Mandarin courses; (2) naïve English speakers; and (3) native Mandarin speakers. A cross-boundary tone pair and a within-category tone pair derived from tonal contrasts (Mandarin Tone 1/Tone 4; Tone 2/Tone 3) with equal physical/acoustical distance were used in an auditory oddball paradigm. For native Mandarin speakers, the cross-category deviant elicited a larger MMN over left hemisphere sensors and larger P300 responses over both hemispheres relative to within-category deviants, suggesting categorical perception of tones at both pre-attentive and attentional stages of processing. In contrast, native English speakers and Mandarin learners did not demonstrate categorical effects. However, learners of Mandarin showed larger P300 responses than the other two groups, suggesting heightened sensitivity to tones and possibly greater attentional resource allocation to tone identification.

The present study investigated the synthesis of mesoporous hollow carbon spheres (MHCS) and magnetic mesoporous hollow carbon spheres with core-shell structures (Fe3O4@MHCS). Two acetylcholinesterase sensors (acetylcholinesterase/mesoporous hollow carbon spheres/glassy carbon electrode (AChE/MHCS/GCE) and acetylcholinesterase/core-shell magnetic mesoporous hollow carbon spheres/glassy carbon electrode (AChE/Fe3O4@MHCS/GCE) based on mesoporous carbon materials were prepared. Under the optimum conditions, using Malathion as the model compound, the developed biosensors showed a wide detection range, low detection limit, good reproducibility, and high stability. The AChE/MHCS/GCE electrochemical sensor response exhibited two good linear ranges at the incubation time of 10 min at the Malathion concentration ranges of 0.01 to 100 ppb and 100 to 600 ppb, with a detection limit of 0.0148 ppb (S/N = 3). The AChE/Fe3O4@MHCS/GCE electrochemical sensor that was operated with an incubation time of 12 min at the malathion concentration ranges between 0.01–50 ppb and 50–600 ppb had a detection limit of 0.0182 ppb (S/N = 3). Moreover, the AChE/MHCS/GCE and AChE/Fe3O4@MHCS/GCE biosensors were effective for the detection of real samples, and were demonstrated to be suitable for the field-testing of organophosphorus pesticide (OP) residues.

This study explored interpersonal influences on electrophysiological responses during the anticipation of tactile stimulation. It is well-known that broad, negative-going potentials are present in the event-related potential (ERP) between a forewarning cue and a tactile stimulus. It has also been shown that the alpha-range mu rhythm shows a lateralized desynchronization over central electrode sites during anticipation of tactile stimulation of the hand. The current study used a tactile discrimination task in which a visual cue signaled that an upcoming stimulus would either be delivered 1500ms later to the participant's hand, to a task partner's hand, or to neither person. For the condition in which participants anticipated the tactile stimulation to their own hand, a negative potential (contingent negative variation, CNV) was observed in the ERP at central sites in the 1000ms prior to the tactile stimulus. Significant mu rhythm desynchronization was also present in the same time window. The magnitudes of the ERPs and of the mu desynchronization were greater in the contralateral than in the ipsilateral hemisphere prior to right hand stimulation. Similar ERP and EEG changes were not present when the visual cue indicated that stimulation would be delivered to the task partner or to neither person. The absence of social influences during anticipation of tactile stimulation, and the relationship between the two brain signatures of anticipatory attention (CNV and mu rhythm) are discussed.

right hemisphere at Time 3. In sum, longitudinal findings showed large between-and within-subject variability in rate of change as well as time to reach neural developmental milestones (e.g., presence of a detectable M100 response). Findings also demonstrated the need to examine whole-brain activity, given hemisphere differences in the rate of auditory cortex maturation. Pediatric research will need to take such normal variability into account when seeking clinical auditory markers.

The focus of the current study is on a particular aspect of tactile perception: categorical segmentation on the body surface into discrete body parts. The MMN has been shown to be sensitive to categorical boundaries and language experience in the auditory modality. Here we recorded the somatosensory MMN (sMMN) using two tactile oddball protocols and compared sMMN amplitudes elicited by within- and across-boundary oddball pairs. Both protocols employed the identity MMN method that controls for responsivity at each body location. In the first protocol, we investigated the categorical segmentation of tactile space at the wrist by presenting pairs of tactile oddball stimuli across equal spatial distances, either across the wrist or within the forearm. Amplitude of the sMMN elicited by stimuli presented across the wrist boundary was significantly greater than for stimuli presented within the forearm, suggesting a categorical effect at an early stage of somatosensory processing. The second protocol was designed to investigate the generality of this MMN effect, and involved three digits on one hand. Amplitude of the sMMN elicited by a contrast of the third digit and the thumb was significantly larger than a contrast between the third and fifth digits, suggesting a functional boundary effect that may derive from the way that objects are typically grasped. These findings demonstrate that the sMMN is a useful index of processing of somatosensory spatial discrimination that can be used to study body part categories.

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