Currently, coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been reported in almost all countries globally. No effective therapy has been documented for COVID-19, and the role of convalescent plasma therapy is unknown. In the current study, 6 patients with COVID-19 and respiratory failure received convalescent plasma a median of 21.5 days after viral shedding was first detected, all tested negative for SARS-CoV-2 RNA within 3 days after infusion, and 5 eventually died. In conclusion, convalescent plasma treatment can end SARS-CoV-2 shedding but cannot reduce the mortality rate in critically ill patients with end-stage COVID-19, and treatment should be initiated earlier.
The reaction between bis(trialkyltin) chalcogenides
and trimethylaluminum results in the
formation of bis(dimethylaluminum) chalcogenides,
(Me2Al)2E, where E is S, Se, or
Te.
Reaction between the latter and carbonyl groups (but not
carboxylic acids or esters) converts
them to carbon−chalcogen double-bond (CE) compounds. Using
this procedure, we have
successfully synthesized several telluro- and selenocarbonyl compounds.
The first successful
synthesis of an isolable, crystalline telluroformamide,
4-(telluroformyl)morpholine (3c,
C5H9NOTe), and its crystal structure are reported. Also, the syntheses
and crystal structures of
a γ-tellurolactam, 1-methyl-2-telluroxopyrroline (3d,
C5H9NTe), and two selenoamides,
N,N-diphenylselenoformamide (3a,
C13H11NSe) and
N-methyl-N-(4-nitrophenyl)
selenoformamide
(3b,
C8H8N2O2Se) are
described.
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