Polyimide (PI) aerogels have attracted great attention owing to their low density and excellent thermal stability. However, hydrophobic surface modification is required for PI aerogels to improve their ability in oil/water separation due to their amphiphilic characteristic. Two-dimensional MXenes (transition metal carbides/nitrides) can be utilized as nanofillers to enhance the properties of polymers because of their unique layered structure and versatile interface chemistry. Herein, the robust, lightweight, and hydrophobic PI/MXene three-dimensional architectures were fabricated via freeze-drying of polyamide acid/MXene suspensions and thermal imidization. Polyamide acid was synthesized using N-N-dimethylacetamide and 4,4′-oxydianiline. MXene (Ti3C2T x ) dispersion was obtained via the etching of Ti3AlC2 and ultrasonic exfoliation. Taking advantage of the strong interaction between PI chains and MXene nanosheets, the interconnected, highly porous, and hydrophobic PI/MXene aerogels with low density were fabricated, resulting in the improved compressive performance, remarkable oil absorption capacity, and efficient separation of oil and water. For the PI/MXene-3 aerogel (weight ratio, 5.2:1) without any surface modification, the water contact angle was 119° with a density of 23 mg/cm3. This aerogel can completely recover to its original height after 50 compression–release cycles, exhibiting superelasticity and exceptional fatigue-resistant ability. It also showed high absorption capacities to various organic liquids ranging from approximately 18 to 58 times of their own weight. This hybrid aerogel can rapidly separate the chloroform, soybean oil, and liquid paraffin from the water–oil system. The thermally stable hybrid aerogel also exhibited excellent fire safety properties and outstanding reusability under an extreme environment.

Transduction of mechanical forces and chemical signals affect every cell in the human body. Fluid flow in systems such as the lymphatic or circulatory systems modulates not only cell morphology, but also gene expression patterns, extracellular matrix protein secretion and cell-cell and cell-matrix adhesions. Similar to the role of mechanical forces in adaptation of tissues, shear fluid flow orchestrates collective behaviours of adherent cells found at the interface between tissues and their fluidic environments. These behaviours range from alignment of endothelial cells in the direction of flow to stem cell lineage commitment. Therefore, it is important to characterize quantitatively fluid interface-dependent cell activity. Common macro-scale techniques, such as the parallel plate flow chamber and vertical-step flow methods that apply fluid-induced stress on adherent cells, offer standardization, repeatability and ease of operation. However, in order to achieve improved control over a cell's microenvironment, additional microscale-based techniques are needed. The use of microfluidics for this has been recognized, but its true potential has emerged only recently with the advent of hybrid systems, offering increased throughput, multicellular interactions, substrate functionalization on 3D geometries, and simultaneous control over chemical and mechanical stimulation. In this review, we discuss recent advances in microfluidic flow systems for adherent cells and elaborate on their suitability to mimic physiologic micromechanical environments subjected to fluid flow. We describe device design considerations in light of ongoing discoveries in mechanobiology and point to future trends of this promising technology.

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Two population balance approaches based on the MUltiple-SIze-Group (MUSIG) model and one-group Average Bubble Number Density (ABND) model for handling the bubble size distribution of gas-liquid bubbly flows under isothermal conditions are assessed. Three forms of coalescence and breakage mechanisms by Wu et al. (1998), Hibiki and Ishii (2002) and Yao and Morel (2004) are incorporated in the ABND model. To examine the relative merits of both approaches, local radial distributions of five primitive variables in bubbly flows: void fraction, Sauter mean bubble diameter, interfacial area concentration, and gas and liquid velocities, are compared against the experimental data of Liu and Bankoff (1993a,b) and Hibiki et al. (2001). In general, both of the ABND model and MUSIG model predictions yield close agreement with experimental results. To account for the range of different bubble sizes in the gas-liquid bubbly flows, the resolution required is achieved through the application of the MUSIG model. Nevertheless, computational times increase by a factor of two when compared to applying the simpler ABND model. To further exploit the models' capabilities, investigations are carried out by extending the two population approaches beyond the bubbly flow regime of higher void fraction, particularly in the transition regime. The numerical results are found to be grossly over-predicted, which expose the inherent limitations of the models. It is known that bubbles in this regime are generally highly distorted and closely packed instead of spherically shape and allowed to move freely in bubbly flow regime.