Summary
A purified antigenic material isolated from E. typhosa cultured in a synthetic medium in total dosage of 0.1 mg administered by subcutaneous injection in man has been demonstrated to produce mouse-protective antibody in greater amounts than 2.5 ml of two standard bacterial vaccines. This response was attained with less local and constitutional reactions than those following the use of the bacterial vaccines. The intracutaneous administration of bacterial vaccines was found less effective than the subcutaneous route. Certain advantages of this purified antigen are discussed.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.