The
merger of photoredox catalysis with transition metal catalysis,
termed metallaphotoredox catalysis, has become a mainstay in synthetic
methodology over the past decade. Metallaphotoredox catalysis has
combined the unparalleled capacity of transition metal catalysis for
bond formation with the broad utility of photoinduced electron- and
energy-transfer processes. Photocatalytic substrate activation has
allowed the engagement of simple starting materials in metal-mediated
bond-forming processes. Moreover, electron or energy transfer directly
with key organometallic intermediates has provided novel activation
modes entirely complementary to traditional catalytic platforms. This
Review details and contextualizes the advancements in molecule construction
brought forth by metallaphotocatalysis.
Investigation into the biological function of 5-benzylidene-4-oxazolidinones revealed dose-dependent inhibition of biofilm formation in Methicillin-resistant S. aureus (MRSA). This structurally unusual class of small molecules inhibit up to 89% of biofilm formation with IC50 values as low as 0.78 μM, and disperse pre-formed biofilms with IC50 values as low as 4.7 μM. Together, these results suggest that 4-oxazolidinones represent new chemotypes to enable the study of bacteral biofilms with small molecule chemical probes.
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