IT was shown [Gray et al. 1937] that the therapeutic action of p-aminobenzenesulphonamide (sulphanilamide) persisted undiminished in certain of its derivatives, which were considerably less toxic to the host than the parent substance. It was found later [Buttle et al. 1937; Fourneau et al. 1937, 1] that 4:4'-diaminodiphenylsulphone was much more active than sulphanilamide, but also much more toxic, and the present paper describes attempts to reduce the toxicity relative to. the activity in a similar way.
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