Annular pustular psoriasis (APP) is a rare form of pustular psoriasis with a chronic recurrent course and good prognosis. We report three cases of APP in children, two of whom were siblings. Review of the medical literature reveals that a disproportionately high percentage of cases of APP occur in children. In some cases topical therapy can clear the condition, although in severe or recalcitrant disease, systemic therapy may be necessary.
Malakoplakia is a rare, chronic disease with pleomorphic presentation. It occurs most frequently in immunocompromised patients. It is believed that this entity represents an unusual response to bacterial infection in which macrophages fail to phagocytose them properly. It involves many organs, particularly the urinary and gastrointestinal tracts. It is uncommon on the skin and less common in children. The diagnosis is usually based on histopathologic findings.
El uso de agentes biológicos para el tratamiento de la psoriasis permite desarrollar una estrategia terapéutica a largo plazo, pero, como resultado de un posible desbalance en los perfiles de respuesta inmune, introducen nuevos efectos colaterales. Las reacciones adversas cutáneas relacionadas al uso de secukinumab son infrecuentes, las más comunes son la urticaria y las infecciones. Se presenta el caso de un paciente con psoriasis que mostró una dermatitis vesiculosa palmoplantar luego del inicio del tratamiento con secukinumab.
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