Malakoplakia

Rubinson, Rebeca; Mendes, Veronica S.; Sánchez, Graciela; Costantini, S.

doi:10.1111/j.1525-1470.2011.01467.x

Cited by 7 publications

(9 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Clinically, malakoplakia overlaps with malignancies given the presence of progressively enlarging masses. Histologically, tumor‐forming histiocytic disorders such as Langerhans cell histiocytosis, Rosai‐Dorfman, and Erdheim‐Chester disease, granulocytic, histiocytic, and follicular interdigitating cell sarcomas need to be considered and excluded by pertinent immunophenotypic and molecular‐genetic studies 7,14 . Additional noninfectious/non‐neoplastic granulomatous disorders to consider are sarcoidosis and inherited chronic granulomatous disease.…”

Section: Discussionmentioning

confidence: 99%

“…In our case, the malakoplakia displayed initially as liver‐like mass, but later extended into the adjacent abdominal wall and skin. Reported treatment options include long‐term antibiotics, surgical resection, and discontinuation or tapering of immunosuppressants when possible 7,14 . Surgical resection was not pursued in this case due to the size and location of the bile ducts and portal vessels.…”

Section: Discussionmentioning

confidence: 99%

“…Reported treatment options include long-term antibiotics, surgical resection, and discontinuation or tapering of immunosuppressants when possible. 7,14 Surgical resection was not pursued in this case due to the size and location of the bile ducts and portal vessels.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Successful treatment of malakoplakia of the liver and skin in a pediatric liver transplant patient

Gerard

Mesa

Danziger‐Isakov

et al. 2023

Pediatric Transplantation

View full text Add to dashboard Cite

Malakoplakia is a rare granulomatous infectious process that affects patients with primary or secondary immunodeficiency. 1 Abnormal macrophage bactericidal activity leads to mass-forming aggregates of histiocytes containing bacteria and pathognomonic basophilic inclusions called Michaelis-Gutmann bodies (MGB). [2][3][4][5][6] The latter are concentrically laminated, round to ovoid concretions of calcium and iron that form within phagolysosomes with bacteria. Histiocytes containing MGB are called "von Hansemann cells" in honor of the pathologist who first described them. The most common site of involvement is the genitourinary (GU) tract, but lesions have been documented in the gastrointestinal (GI) tract, lungs, skin, bone, conjunctiva, adrenal gland, and very rarely in the liver. 7 Of approximately 40 cases of cutaneous malakoplakia documented in the literature, just 4 affected pediatric patients. 1,5,[8][9][10] Only 7 cases of

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Successful treatment of malakoplakia of the liver and skin in a pediatric liver transplant patient

Gerard

Mesa

Danziger‐Isakov

et al. 2023

Pediatric Transplantation

View full text Add to dashboard Cite

show abstract

“…6,7 Most patients diagnosed with malakoplakia are immunocompromised or immunosuppressed adults, such as solid organ transplant recipients, although rarely it has been diagnosed in children. 9 Malakoplakia most frequently occurs in adult males involving the urogenital tract (such as the bladder, ureters, kidney, and male prostate) and clinically presents with urinary symptoms and/or recurrent E. coli bladder infections. Malakoplakia is extremely uncommon in the skin, F I G U R E 1 Friable ulcer on the left medial ankle.…”

Section: Discussionmentioning

confidence: 99%

“…although various cutaneous sites have been documented in the literature and they include: scalp, forehead, cheek, neck, axilla, buttocks, perianal region, and thigh. [9][10][11][12][13][14][15][16][17][18] Other clinical settings in which cutaneous malakoplakia has been reported include patients with connective tissue disease, sarcoidosis, diabetes mellitus, and HIV/AIDS. 17 Due to the variability in clinical presentation, cutaneous malakoplakia is best diagnosed using characteristic histopathologic features seen in a skin biopsy.…”

Section: F I G U R E 5 a Von Kossa Special Stain Highlights Calcified...mentioning

confidence: 99%

Cutaneous malakoplakia arising on the ankle of a patient with pyoderma gangrenosum

Whittington,

Saleh,

Schadler

et al. 2023

J Cutan Pathol

View full text Add to dashboard Cite

Malakoplakia is a rare chronic inflammatory condition that most commonly involves the urogenital tract. Cutaneous malakoplakia is extremely rare and many patients diagnosed with skin involvement are immunosuppressed. While the clinical presentation of cutaneous malakoplakia is variable, the histopathologic features are quite distinct and include sheets of closely packed dermal histiocytes with foamy‐appearing cytoplasm and Michaelis–Gutmann bodies that are positive with certain immunohistochemical stains. While the exact pathogenesis of malakoplakia is unknown, it has been associated with certain bacterial infections. Treatment generally involves a combination of surgery and antimicrobial agents and/or modulation of immunosuppressant therapy if appropriate. Herein, the authors report a unique case of cutaneous malakoplakia arising in a patient on chronic immunosuppressive therapy for the management of pyoderma gangrenosum.

show abstract

A Case of Cutaneous Malakoplakia in the Head and Neck Region and Review of the Literature

Coates

Pero

Nassif

2016

Head and Neck Pathol

View full text Add to dashboard Cite

Malakoplakia is a rare inflammatory condition that typically occurs in the urinary tract. The cutaneous form is less prevalent, and most commonly occurs in the perianal or genital regions. Here we present a 61 year old lady with cutaneous malakoplakia of the neck, which was successfully treated with surgical excision and a prolonged course of ciprofloxacin. We follow our case report with a discussion and literature review of all seventeen previously reported cutaneous head and neck malakoplakia cases from the literature. A diagnosis of cutaneous malakoplakia should be considered in nodular, ulcerated or discharging lesions that are refractory to treatment. Histology is essential, not only to diagnose malakoplakia, but also to exclude other important differential diagnoses, such as malignancy. Combined surgical excision and prolonged antibiotic courses appear to have the highest success rate. Antibiotics should be culture specific, but quinolones appear to be the best empirical choice.

show abstract

Malakoplakia

Cited by 7 publications

References 5 publications

Successful treatment of malakoplakia of the liver and skin in a pediatric liver transplant patient

Successful treatment of malakoplakia of the liver and skin in a pediatric liver transplant patient

Cutaneous malakoplakia arising on the ankle of a patient with pyoderma gangrenosum

A Case of Cutaneous Malakoplakia in the Head and Neck Region and Review of the Literature

Contact Info

Product

Resources

About