Cystic fibrosis (CF) is a potentially fatal monogenic disease that causes a progressive multisystemic pathology. Over the last decade, the introduction of CF transmembrane conductance regulator (CFTR) modulator drugs into clinical practice has profoundly modified the lives of many people with CF (PwCF) by targeting the fundamental cause of the disease. These drugs consist of the potentiator ivacaftor (VX-770) and the correctors lumacaftor (VX-809), tezacaftor (VX-661), and elexacaftor (VX-445). In particular, the triple combination of CFTR modulators composed of elexacaftor, tezacaftor, and ivacaftor (ETI) represents a life-changing therapy for the majority of PwCF worldwide. A growing number of clinical studies have demonstrated the safety and efficacy of ETI therapy in both short- and long-term (up to two years of follow-up to date) and its ability to significantly reduce pulmonary and gastrointestinal manifestations, sweat chloride concentration, exocrine pancreatic dysfunction, and infertility/subfertility, among other disease signs and symptoms. Nevertheless, ETI therapy-related adverse effects have also been reported, and close monitoring by a multidisciplinary healthcare team remains vital. This review aims to address and discuss the major therapeutic benefits and adverse effects reported by the clinical use of ETI therapy for PwCF.
A presença de corantes na água, mesmo em pequenas concentrações é prejudicial, pois podem impedir a penetração da luz e prejudicar a eficiência da fotossíntese, causando sérios danos à fauna e flora destes locais. Devido à sua alta toxicidade os corantes também podem causar danos graves aos seres humanos, como disfunção nos sistemas renais, do reprodutivo, além do fígado, cérebro e sistema nervoso central. Entre os métodos usados no tratamento de água, a biossorção se apresenta como uma alternativa interessante devido sua alta seletividade, eficiência e baixo custo, propondo a utilização de produtos residuais e subprodutos. Tendo isso em vista, o presente estudo avaliou a capacidade de
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