Certain preoperative anatomical features may lead the surgeon to choose one particular incision pattern in preference to another, but in this study, it was found that one technique was essentially as good as the other. This suggests that the technique for closure of the underlying tissues is probably of more importance.
Provided in this article are the quantitative and qualitative morphological results describing the action of several nanostructured surfaces for bactericidal and bacteriostatic action. Results are also provided to illustrate microbial corrosion and its impact. Biofilm formation is correlated to colony formation. Nanostructured surfaces, i.e. surfaces with welded nanoparticles are noted to display biocidal activity with varying efficacies. Porous nanostructures, on stainless steel and copper substrates, made of high purity Ag, Ti, Al, Cu, MoSi2, and carbon nanotubes, are tested for their efficacy against bacterial colony formation for both gram-negative, and gram-positive bacteria. Silver and Molybdenum disilicide (MoSi2) nanostructures are found to be the most effective bactericidal agents with MoSi2 being particularly effective in both low and high humidity conditions. Bacteriostatic activity is also noted. The nanostructured surfaces are tested by controlled exposures to several microbial species including (Gram+ve) bacteria such as Bacillus Cereus and (Gram-ve) bacteria such as Enterobacter Aerogenes. The resistance to simultaneous exposure from diverse bacterial species including Arthrobacter Globiformis, Bacillus Megaterium, and Cupriavidus Necator is also studied. The nanostructured surfaces were found to eliminates or delay bacterial colony formation, even with short exposure times, and even after simulated surface abrasion. The virgin 316 stainless steel and copper substrates, i.e. without the nanostructure, always displayed rapid bacterial colony evolution indicating the lack of antimicrobial action. The efficacy of the nanostructured surface against colony formation (bacterial recovery) for E-Coli (two strains) and virus Phi 6 Bacteriophage with a host Pseudomonas Syringae was also studied. Preliminary results are presented that also show possible anti-fungal properties by the nanostructured MoSi2. When comparing antimicrobial efficacy of flat polished surfaces (no curvature or nanostructure) with nanostructure containing surfaces (high curvature) of the same chemistry, shows that bacterial action results from both the nanostructure size and chemistry.
Repair of unilateral cleft lip is a fascinating and challenging procedure. Although a great number of operations have been described for the unilateral cleft lip repair, none fulfill all the plastic surgical criteria, and in most cases, cleft lip repairs require secondary operations in an attempt to achieve described goals of primary cheiloplasty. The Afroze incision is a combination 2 incisions, that is, the Millard incision on the noncleft side and Pfeiffer incision on the cleft side. The flap design is the Millard flap on the noncleft side rotated downward, and the peak of the distal curve of the Pfeiffer flap is positioned in the triangular defect formed by the movement of the Millard flap. The proximal curve lengthens downward to receive the Millard's "C" flap. The advantage of this technique is that there is no tension on the postoperative scar because the incision is essentially horizontal in nature, and the contracture of the scar occurs horizontally rather than vertically. Primary septal repositioning is performed, which provides stability and exact positioning of the previously lifted alar crus of the cleft side and nasal tip, and the nose can grow in a balanced way with equal muscular force being exerted on both sides. This incision can be used in all types of complete unilateral cleft lip regardless of the width of the cleft, shortening the cleft lip segment.
Background Cleft lip palate (CLP) is a common congenital anomaly with multifactorial etiology. Many polymorphisms at different loci on multiple chromosomes were reported to be involved in its etiology. Genetic research on a single multigenerational American family reported 18q21.1 locus as a high-risk locus for nonsyndromic CLP (NSCLP). However, its association in multiple multiplex families and Indian population is not analyzed for its association in NSCLP. Aim This study was aimed to evaluate whether high-risk single nucleotide polymorphisms (SNPs) on chromosome 18q21.1 are involved in the etiology of NSCLP in multiplex Indian families. Materials and Methods Twenty multigenerational families affected by NSCLP were selected for the study after following inclusion and exclusion criteria. Genomic DNA was isolated from the affected and unaffected members of these 20 multiplex families and sent for genetic analysis. High-risk polymorphisms, such as rs6507872 and rs8091995 of CTIF, rs17715416, rs17713847 and rs183559995 of MYO5B, rs78950893 of SMAD7, rs1450425 of LOXHD1, and rs6507992 of SKA1 candidate genes on the 18q21.1 locus, were analyzed. SNP genotyping was done using the MassARRAY method. Statistical analysis of the genomic data was done by PLINK. Results Polymorphisms followed the Hardy–Weinberg equilibrium. In the allelic association, all the polymorphisms had a p-value more than 0.05. The odds ratio was not more than 1.6 for all the SNPs. Conclusion High-risk polymorphisms, such as rs6507872 and rs8091995 of CTIF, rs17715416, rs17713847 and rs183559995 of MYO5B, rs78950893 of SMAD7, rs1450425 of LOXHD1, and rs6507992 of SKA1 in the locus 18q21.1, are not associated with NSCLP in Indian multiplex families.
Diagnosis and management of non-specific, atypical, and non-dental pain are challenging. We hereby report a case of a 23-year-old female who presented with a complaint of intermittent dull ache over her lower front anterior teeth with no radiographic findings. She was diagnosed after history, imaging, and neurology consultation and treated conservatively with complete remission of symptoms. Proper history and counseling are mandatory for all patients. It is important to recognize patients with underlying neurological conditions and take adequate interdepartmental consultation before labeling complaints psychogenic or carrying out unwarranted dental treatment.
Aims This study aimed to obtain an update on the epidemiologic data of maxillofacial injuries with an analysis of current aetiology and associated factors encountered at a major Tertiary Care Centre of North India. Materials and methods This retrospective study was conducted in a Tertiary Care Centre in Uttarakhand over 2 years. The demographics, aetiology, seatbelt/helmet use, alcohol consumption at the time of injury, site of the fracture, other associated injuries and type of intervention were recorded. Results The male:female ratio was 4.2:1. A peak prevalence was found in the third decade (mean age 23.6). Road traffic accidents were the most common cause of trauma (76.9%). Maxillofacial injuries were higher in those who did not use a seatbelt or helmet (85.1%). Intoxication at the time of injury was a major factor, especially in accidents. Drivers were found to be injured more (74.7%) than pillion riders or passengers. The incidence of fractures was highest in monsoons (30%). Mandibular (37.8%) and zygomatic (20%) fractures were most commonly encountered. The most common site of mandibular fractures was parasymphysis (30.6%). Fractures were treated by open reduction and internal fixation. Concomitant neurological and orthopaedic injuries were common in patients sustaining maxillofacial injuries. Conclusion Road traffic accidents continue to be responsible for maximum trauma. A multidisciplinary assessment of every trauma victim is essential. This study can help formulate rigorous injury preventive schemes by distinguishing and analysing maxillofacial trauma. Advocation and strict implementation of helmet and seatbelt use with a heavy penalty for drinking and driving can lead to the reduction of maxillofacial injuries.
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