We tested a model describing the characteristics of sexually aggressive men that may also be useful for understanding the causes of other antisocial acts against women. This model hypothesizes that sexual aggressors can be identified by two sets of characteristics, labeled hostile masculinity and impersonal sex. To test this model, we followed up a sample of men 10 years after first studying them when they were young adults. We sought to predict which men would be in distressed relationships with women, be aggressive sexually, be nonsexually aggressive, or some combination of these. These behaviors were measured not only by questioning the men themselves but also by questioning many of the men's female partners. Some couples' videotaped conversations were also analyzed. The data supported the ability of the model to predict behavior 10 years later. We also developed the model further and identified the common and unique characteristics contributing to sexual aggression as compared with the other conflictual behaviors studied. The data supported the usefulness of hierarchical modeling incorporating both general factors that contribute to various interpersonal conflicts as well as specific factors uniquely pertaining to dominance of women.

The health effects of a binge pattern of alcohol consumption have not been widely investigated. The objective of this study was to evaluate the cardiovascular consequences of binge drinking (consumption of eight or more drinks at one sitting) and usual (nonbinge) drinking in a longitudinal, population-based study. Data obtained from 1,154 men and women aged 18-64 years interviewed in Winnipeg, Manitoba, Canada, in 1990 and 1991 were linked to health care utilization and mortality records. Using an 8-year follow-up period, the authors performed separate Cox proportional hazards regression analyses for men and women on time to first event for physician visits, hospitalizations, and deaths due to coronary heart disease, hypertension, and other cardiovascular disease. Binge drinking increased the risk of coronary heart disease in both men (hazard ratio (HR) = 2.26, 95% confidence interval (CI): 1.22, 4.20) and women (HR = 1.10, 95% CI: 1.02, 1.18). It increased the risk of hypertension in men (HR = 1.57, 95% CI: 1.04, 2.35) but not in women. Binge drinking had no effect on the risk of other cardiovascular disease. In contrast, usual drinking had significant cardioprotective effects in both men and women. Thus, the harmful effects of binge drinking on cardiovascular disease morbidity and mortality can be disaggregated from the protective effects of usual drinking at various levels of consumption.

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Recent theories of drug dependence propose that the transition from occasional recreational substance use to harmful use and dependence results from the impact of disrupted midbrain dopamine signals for reinforcement learning on frontal brain areas that implement cognitive control and decision-making. We investigated this hypothesis in humans using electrophysiological and behavioral measures believed to assay the integrity of midbrain dopamine system and its neural targets. Our investigation revealed two groups of dependent individuals, one characterized by disrupted dopamine-dependent reward learning and the other by disrupted error learning associated with depression-proneness. These results highlight important neurobiological and behavioral differences between two classes of dependent users that can inform the development of individually tailored treatment programs.

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