Objective: We aimed to evaluate the demographic, clinical, laboratory and electrophysiological findings of patients with inpatient Guillain-Barré syndrome in our clinics and to investigate the effect of these parameters on the prognosis of the disease. Materials and Methods: Between January 2014 and April 2018, file records of patients admitted to our clinics with the diagnosis of Guillain-Barré syndrome were retrospectively reviewed. Demographic characteristics, clinical, laboratory and electrophysiological findings of the patients at the time of admission were recorded. Patients were clinically graded according to the Hughes classification at the time of admission and on the 3 rd month after discharge. Results: In the study, 25 of the 51 patients were male (49%) and 26 were female (51%) and the mean age was 54.21±17.32 years. According to clinical and electrophysiologic diagnosis, 34 patients (66.7%) had acute inflammatory demyelinating polyradiculoneuropathy, 9 patients (17.6%) had acute motor axonal neuropathy, 6 patients (11.8%) had acute motor sensory axonal neuropathy and 2 patients (3.9%) had Miller Fisher syndrome. According to Hughes scoring on the 3 rd month after discharge, 31 patients (60.8%) had in good prognosis (Hughes score ≤2) and 20 patients (39.2%) had in poor prognosis group (Hughes score >2). In the comparison between the two groups according to clinical, demographic, and laboratory parameters, older age (≥50), high Hughes score at admission, weakness in extremities as first complaint, the presence of complications, need for mechanical ventilation and presence of gastroenteritis as a leading infection were evaluated as prognostic factors. Conclusion: The most common variant of Guillain-Barré syndrome in our study was acute inflammatory demyelinating polyradiculoneuropathy. Older age (≥50), high Hughes score at admission, weakness in extremities as the first symptom, presence of complications, need for mechanical ventilation, and presence of gastroenteritis as a precursor infection were poor prognostic factors.
ÖZET: Uyku sağlık ve yaşamımızın iyi bir şekilde devamı için önemli bir role sahiptir. Kaliteli uyku zihinsel sağlığımızı, fiziksel sağlığımızı, hayat kalitemizı korumamıza yardım eder ve güvenliğimiz için gereklidir. Uykunun başlatılması ve sürdürülmesi kortikal ve subkortikal birçok beyin bölgesinin işlevi ile gerçekleşir. Uykunun başlatılmasında öncelikle ön hipotalamustan gelen döngüsel girdiler ve endojen kimyasal uyarılar doğrultusunda hipotalamusta ventrolateral preoptik çekirdeğin rol aldığı kabul edilir. Normal uykunun hızlı göz hareketleri (REM) ve hızlı göz hareketlerinin olmadığı (NREM) olarak iki dönemi vardır. REM uykusunda asetilkolin ve serotonin, NREM uykusunda ise serotonin ve GABA önemli rol oynayan nörotrasmitterlerdir. NREM ve REM gece boyunca 90-110 dakikalık sikluslar şekinde gecede 5-6 kez tekrarlar. NREM gecenin ilk bölümünde, REM ikinci döneminde belirgin olarak gözlenir. Uyku bozuklukları görüldüğü döneme göre 3 grupta incelenebilir: (1) REM döneminde görülenler, (2) NREM döneminde görülenler, (3) Uykunun herhangi bir döneminde görülenler. Uyku bozukluğu olan hastalar yol veya iş kazaları, sosyal uyumsuzluk, akademik veya mesleki performansta düşme gösterebilirler. Bu yüzden uyku bozukluğu detaylı olarak incelenmesi gereken önemli bir durumdur. ANAHTAR KELİMELER: Uyku, kalite, REM, NREM, ICD 3 sınıflama. QUALITY SLEEP AND SLEEP DISORDERSABSTRACT: Sleep plays a vital role in good health and well-being throughout your life. Getting enough quality sleep at the right times can help protect your mental health, physical health, quality of life, and safety. Sleep initiation and maintenance take place with the function of a lot of cortical and subcortical region of the brain. In the initiation of sleep, it is accepted that primarily cyclic inputs from the hypothalamus and anterior hypothalamus, ventrolateral preoptic nucleus with the signals of endogenous chemical. Normal sleep is divided into two states: rapid eye movement (REM) and non-rapid eye movement (NREM).The major neurotransmitter of REM is acetylcholine and of NREM are GABA and serotonine. In a normal individual, NREM and REM sleep alternate cyclically throughout the night. The NREM-REM cycle repeats itself every 90-110 min, 5-6 times per night. Typically, NREM sleep predominates in the first part of the night, and REM sleep predominates in the second. Sleep disorders can be divided in three groups according to occurence period: (1) Sleep disorders seen in REM, (2) in NREM and (3) in any of REM or NonREM periods. Patients with sleep disorders may effects (road and work accidents), social maladjustment, decreased academic and occupational performance. Thus, sleep disorder is a serious condition that requires investigation, diagnosis and treatment.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.