The single strategy using SI alone is as effective as the combined strategy of SI and RM for removing residual carbon dioxide and consequently preventing PLSP. Therefore, considering the potential risks of pulmonary or hemodynamic complications associated with RM, the single strategy using SI alone might be a better choice than the combined strategy.
Background Rotator cuff tendinopathy is a primary cause of shoulder pain and dysfunction. Several effective nonsurgical treatment methods have been described for chronic rotator cuff tendinopathy. Prolotherapy with polydeoxyribonucleotide (PDRN), which consists of active deoxyribonucleotide polymers that stimulate tissue repair, is a nonsurgical regenerative injection that may be a viable treatment option. The objective of this study was to assess the efficacy of PDRN in the treatment of chronic rotator cuff tendinopathy. Method The records of patients with chronic rotator cuff tendinopathy (n=131) were reviewed retrospectively, and the patients treated with PDRN prolotherapy (n=32) were selected. We measured the main outcome of the shoulder pain and disability index score on a numerical rating scale of average shoulder pain. Results Compared with baseline data, significant improvements in the shoulder pain and disability index and pain visual analog scale scores were demonstrated at one week after the end of treatment, and at one month and three months later. Conclusions PDRN prolotherapy may improve the conservative treatment of painful rotator cuff tendinopathy for a specific subset of patients.
Recently, regenerative medicine utilizing tissue manufacturing has been a creative topic of study, offering promise for resolving the gap between insufficient organ supply and transplantation needs. Moreover, 3D generation of functional organs is seen as the main hope to resolve these issues that will be a major advancement in the field over the next generation. Organ printing is the 3D construction of functional cellular tissue that can replace organs made by additive biofabrication with computational technology. Its advantages offer rapid prototyping (RP) methods for fabricating cells and adjunctive biomaterials layer by layer for manufacturing 3D tissue structures. There is growing interest in applying stem cell research to bio-printing. Recently several bio-printing methods have been developed that accumulate organized 3D structures of living cells by inkjet, extrusion, and laser based printing systems. By printing spatially organized gradients of biomolecules as an extracellular matrix, direct stem cell seeding can then be engineered to differentiate into different lineages forming multiple subpopulations that closely approximate the desired organ. Pliable implementation patches can Stem cells for tissue regeneration can be arranged or deposited onto pliable implementation patches with the purpose of generating functional tissue structures. In this review, current research and advancement of RP-based bio-printing methods to construct synthetic living organs will be discussed. Furthermore, recent accomplishments in bioprinting methods for stem cell study and upcoming endeavors relevant to tissue bioengineering, regenerative medicine and wound healing will be examined.
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