Ultrasound-Guided Prolotherapy with Polydeoxyribonucleotide for Painful Rotator Cuff Tendinopathy

Abstract

Background Rotator cuff tendinopathy is a primary cause of shoulder pain and dysfunction. Several effective nonsurgical treatment methods have been described for chronic rotator cuff tendinopathy. Prolotherapy with polydeoxyribonucleotide (PDRN), which consists of active deoxyribonucleotide polymers that stimulate tissue repair, is a nonsurgical regenerative injection that may be a viable treatment option. The objective of this study was to assess the efficacy of PDRN in the treatment of chronic rotator cuff tendinopathy. Method The records of patients with chronic rotator cuff tendinopathy (n=131) were reviewed retrospectively, and the patients treated with PDRN prolotherapy (n=32) were selected. We measured the main outcome of the shoulder pain and disability index score on a numerical rating scale of average shoulder pain. Results Compared with baseline data, significant improvements in the shoulder pain and disability index and pain visual analog scale scores were demonstrated at one week after the end of treatment, and at one month and three months later. Conclusions PDRN prolotherapy may improve the conservative treatment of painful rotator cuff tendinopathy for a specific subset of patients.

Effects of Human Placenta Extract (Laennec) on Ligament Healing in a Rodent Model

“…Furthermore, the histologic analysis (cellularity, shape, and alignment) results may have included bias. 22) To address this issue, three independent researchers scored the findings separately, and the scores were derived after reaching a consensus regarding any discrepancies in scoring.…”

“…Continuous traction force of 10 N was applied to the MCL for 5 min to create a partial tear injury. 22) The severity of the ligament injury was identified using an electron microscope ( Fig. 2).…”

Comparative Effectiveness of Ultrasound-Guided Intratendinous Prolotherapy Injection with Conventional Treatment to Treat Focal Supraspinatus Tendinosis

“…Shoulder pain is an important condition of the upper extremity occurring in approximately 15 in 1000 patients per year in the outpatient primary care setting and affects one in three individuals during their lifetime [ 1 ]. There were almost 7.5 million visits to the doctors in 2006 due to shoulder pain, and 8–13% involved athletic injuries [ 2 ].…”

“…Normal range of shoulder movement is needed for daily movement, and restrictions to the activities of daily living are remarkable when someone is experiencing shoulder pain. Rotator cuff tendinopathy (RCT) is a main cause of shoulder pain and disability [ 1 ] and occurs in about one in five symptomatic shoulders. It is commonly seen in manual workers, athletes, and elderly; shoulder pain and weakness will interfere with their work, sleep, self-care, physical activities and sports [ 3 ].…”

“…Painful tendinopathy is challenging to treat [ 4 ] and the nonoperative conservative treatment is the first-line treatment for most RCT. The conservative treatment approaches frequently involving rest, activity modification, physical therapy, and pain medication [ 1 ].…”