Asian Pacific J Cancer Prev, 13, 637-640
IntroductionBrain tumors though not frequent, contribute significantly to morbidity because of their relatively poor survival rate. A number studies from Western countries has reported on the pattern, incidence and mortality of brain and central nervous system (CNS) tumors. But no population based data have hitherto been reported on the descriptive epidemiology of brain and CNS tumors from India. So an attempt has been made to present the descriptive analysis of malignant brain and CNS tumors from Delhi.
Materials and MethodsThe data collected by Delhi Population Based Cancer Registry (PBCR) was utilized for this study. The Delhi PBCR was established 1986 in Dr. BRAIRCH, AIIMS, New Delhi with the aim of obtaining reliable cancer morbidity and mortality data among the Delhi urban residents. Delhi, the capital of India covers an area of 1483sq.kms. The age adjusted (world population) incidence rates were 3.9 per 100,000 for males and 2.4 per 100,000 for females. Gliomas were the most frequently reported histology both in males (26.6%) and females (23.2%). A male predominance in incidence was observed for all histological classifications. The rates in Delhi are low compared to the incidences reported from developed countries.
The surgical management of intrinsic brainstem tumors presents a surgical challenge; radical excision yielded a good outcome in the majority of cases. The authors propose a classification system for 'intrinsic' brainstem tumors for defining surgical strategy.
Although pCR rates were higher with docetaxel-based NACT, it did not translate into superior disease-free survival / overall survival compared to anthracycline-based chemotherapies.
Suiamry Twenty-four out of 164 (14%) adult patients with pnrmary germ cell tumours of testis seen over the last 6 years at the Institute Rotary Cancer Hospital (IRCH) of the All India Institute of Medical Sciences (AIIMS), New Delhi, were found to have cryptorchidism. Only one patient had undergone correction. As a result the testes were intra-abdominal in the vast majority, and patients presented late. Twenty-two patients presented with stage Ilb or more advanced disease. Twelve patients had seminoma and the others had mixed or non-seminomatous germ cell tumour (NSGCT), i.e. 50% each. The earlier patients were managed by initial resection followed by radiation and or chemotherapy. As experience grew the seven patients who presented late were given initial chemotherapy followed by resection in those with residual tumours. The probability of overall survival was 0.65 at 36 months and, was not significantly different from survival in 114 patients with tumours of normally descended testis. Early orchipexy facilitates the detection, but whether it reduces the incidence of tumours is controversial. Uncorrected cryptorchidism is now rarely seen in the West, but in India and many other developing countries tumours of uncorrected cryptorchid testes continue to be seen.
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