The unpredictability and intermittency introduced byRenewable Energy Sources (RESs) in power systems may lead to unforeseen peaks of energy production, which might differ from energy demand. To manage these mismatches, a proper communication between prosumers (i.e., users with RESs that can either inject or absorb energy) and active users (i.e., users that agree to have their loads changed according to the system needs) is required.To achieve this goal, the centralized approach used in traditional power systems is no longer possible because both prosumers and active users would like to take part in energy transactions, and a decentralized approach based on transactive energy systems (TESs) and Peer-to-Peer (P2P) energy transactions should be adopted. In this context, theDistributed Ledger Technology (DLT), based on the blockchain concept arises as the most promising solution to enable smart contracts between prosumers and active users, which are safely guarded in blocks with cryptographic hashes. The aim of this paper is to provide a review about the deployment of decentralized TESs and to propose and discuss a transactive management infrastructure. In this context, the concept of Proof of Energy is proposed as a novel consensus protocol for P2P energy exchanges managed by DLT. An application of the proposed infrastructure considering a Virtual Power Plant (VPP) aggregator and residential prosumers endowed with a new transactive controller to manage the electrical storage system is discussed. Q1

Rationale: Cardiac extracellular matrix (ECM) comprises a dynamic molecular network providing structural support to heart tissue function. Understanding the impact of ECM remodeling on cardiac cells during heart failure (HF) is essential to prevent adverse ventricular remodeling and restore organ functionality in affected patients. Objective: We aimed to (i) identify consistent modifications to cardiac ECM structure and mechanics that contribute to HF and (ii) determine the underlying molecular mechanisms. Methods and Results: We first performed decellularization of human and murine ECM (dECM) and then analyzed the pathological changes occurring in dECM during HF by atomic force (AFM), two-photon microscopy, high-resolution 3D image analysis and computational fluid dynamics (CFD) simulation. We then performed molecular and functional assays in patient-derived cardiac fibroblasts (CFs) based on YAP-TEAD mechanosensing activity and collagen contraction assays. The analysis of HF dECM resulting from ischemic (IHD) or dilated cardiomyopathy (DCM), as well as from mouse infarcted tissue, identified a common pattern of modifications in their 3D topography. As compared to healthy heart, HF ECM exhibited aligned, flat and compact fiber bundles, with reduced elasticity and organizational complexity. At the molecular level, RNA sequencing of HF CFs highlighted the overrepresentation of dysregulated genes involved in ECM organization, or being connected to TGFß1, Interleukin-1, TNF-alpha and BDNF signaling pathways. Functional tests performed on HF CFs pointed at mechanosensor YAP as a key player in ECM remodeling in the diseased heart via transcriptional activation of focal adhesion assembly. Finally, in vitro experiments clarified pathological cardiac ECM prevents cell homing, thus providing further hints to identify a possible window of action for cell therapy in cardiac diseases. Conclusions: Our multi-parametric approach has highlighted repercussions of ECM remodeling on cell homing, CF activation and focal adhesion protein expression via hyper-activated YAP signaling during HF.

The class of rings with 1 satisfying the properties of the title is characterized by some separation properties on the prime and maximal spectra, and, in such rings, the map which sends every prime ideal into the unique maximal ideal containing it, is continuous. These results are applied to CiX) to obtain Stone's theorem and the Gelfand-Kolmogoroff theorem. As a side result, the methods give new information on the mapping P-*PC\C*iX) (P a prime ideal of CiX)). Introduction. A ring with an identity possessing the properties of the title will be called a pm-ring. The purpose of this paper is to study some properties of the prime spectrum (P and of the maximal spectrum 3TC of a pm-ring A. The pm-property is strictly related to separation properties of (P and 9TC; specifically, it is equivalent to the normality of (P and implies that 9ÎI is T2, all three conditions being equivalent if the Jacobson radical and the nilradical of A coincide. In a pm-ring A, let u be the map of G> onto 9TC which sends every prime ideal into the unique maximal ideal containing it. One of our main results is the fact that p is continuous ; in fact, the pm-rings are also characterized by the presence of a retraction of

P(~\C*iX) of the prime spectrum of CiX) into the prime spectrum of C*(X), which extend results obtained in [M ] by different techniques.

In this paper, we present the implementation and analysis of our testbed considering the Link Quality Window Size (LQWS) parameter of Optimized Link State Routing (OLSR) and Better Approach To Mobile Ad-hoc Networking (B.A.T.M.A.N.) protocols. We investigate the effect of mobility in the throughput of a Mobile Ad-hoc Network (MANET). The mobile nodes move toward the destination at a regular speed. When the mobile nodes arrive at the corner, they stop for about three seconds. In our experiments, we consider two cases: only one node is moving (mobile node) and two nodes (intermediate nodes) are moving at the same time. We assess the performance of our testbed in terms of throughput, round trip time, jitter and packet loss. From our experiments, we found that throughput of TCP was improved by reducing LQWS.

Due to the opportunities provided by the Internet, more and more people are taking advantage of distance learning courses and during the last few years enormous research efforts have been dedicated to the development of distance learning systems. So far, many e-learning systems are proposed and used practically. However, in these systems the e-learning completion rate is about 30%. One of the reasons is the low study desire when the learner studies the learning materials. In this research, we propose an interactive Web-based e-learning system. The purpose of our system is to increase the e-learning completion rate by stimulating learner's motivation. The proposed system has three subsystems: the learning subsystem, learner support subsystem, and teacher support subsystem. The learning subsystem improves the learner's study desire. The learner support subsystem supports the learner during the study, and the teacher support subsystem supports the teacher to get the learner's study state. To evaluate the proposed system, we developed several experiments and surveys. By using new features such as: display of learner's study history, change of interface color, encourage function, ranking function, self-determination of the study materials, and grouping of learners, the proposed system can increase the learning efficiency.