The aim of this in vitro study was to evaluate the accuracy of different intraoral scanners (IOS), according to different scanning strategies and to the experience of the operator. Six IOS setups were used in this study. Ten scans of a complete epoxy-resin-made maxillary dental arch were performed with each IOS, using four different scanning techniques (manufacturer-suggested scanning strategy, cut-out rescan technique, simplified scanning technique, novel scanning technique). Scans were also performed by an expert operator in the field of digital dentistry. An operator with no experience in the field of intraoral scans performed 10 scans following each of the scanning strategy suggested by the manufacturer. The master model was scanned with an industrial high-resolution reference scanner to obtain a highly accurate digitized reference model. All the digital models were aligned with the reference model using a software aimed at comparing the STL files. A total of n = 300 scans were performed. Once the data were pooled, Medit i700 and Primescan obtained the best results in terms of both trueness and precision, showing no statistically significative differences (p > 0.05) to the first and the second scanning technique, Medit i700 scanner allowed to obtain the best values both in terms of trueness (24.4 ± 2.1 μm and 21.4 ± 12.9 μm, respectively) and precision compared to other IOS (23.0 ± 1.6 μm and 30.0 ± 18.0 μm, respectively). When considering the third scanning technique, Medit i700 recorded the best values in terms of trueness while Primescan recorded the best values in terms of precision (24.0 ± 2.7 μm and 26.8 ± 13.7 μm, respectively). When considering the two operators, significant differences between the two were found only with Medit i700 (p < 0.001). The examined IOS showed statistically significant differences in terms of trueness and precision. The used scanning strategy is a factor influencing the accuracy of IOS. Considering the expertise of the operators, clinically scanning strategies are not operative sensitive in terms of accuracy.
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