Our study showed the effectiveness of alpha-tocopherol acetate topic treatment in elderly patients affected by CRS after FESS, in improving and speeding up the process of restoring the sinonasal mucosa, compared to another topic medication.
Clinical practice in dermatology indicates that alpha-tocopherol acetate is beneficial in xerosis, hyperkeratosis, asteatotic eczema, atopic dermatitis, superficial burns, cutaneous ulcers, onychoschizia and, in general, skin diseases in which an inflammatory process is activated. The positive effect results from the combination of biological activity, the absence of adverse reactions, and the physical effect of the alpha-tocopherol acetate oil. The viscosity of this oil in bulk phase accounts for a remarkable moisturizing effect and minimization of transepidermal water loss. This effect combines well with the antioxidant capacity of alpha-tocopherol released from the ester, and the recently emerging effect on reprogramming of gene expression.
Background This study compared the effectiveness and tolerability of alpha-tocopherol acetate nasal spray (ATANS) to those of beclomethasone nasal spray (BNS) and loratadine (LT) for the treatment of pollen-induced allergic rhinitis. Methods This active-controlled, patient-preference, observational trial lasted 7 days. Tested variables were Authors' contributions Ralph Mösges, Giorgio Panin, and Jürgen Lamprecht conceptualized and designed the study. Ursula Pieper-Fürst conducted the trial. Kija Shah-Hosseini performed the statistical analyses. Ursula Pieper-Fürst and Van-Anh Dao wrote the manuscript. All authors approved the final manuscript for submission. Availability of data and materials The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.
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