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BackgroundThe aim of our study was to assess the relationship between soluble Klotho (s-Klotho) and carotid intima–media thickness (CIMT) and left ventricular (LV) dysfunction in hemodialysis (HD) patients.MethodsThis is a cross-sectional study conducted on 88 patients with end-stage renal disease on regular HD. Serum levels of calcium, phosphorus, parathyroid hormone, and C-reactive protein were measured. The serum levels of s-Klotho and fibroblast growth factor-23 (FGF-23) were measured using an Enzyme linked immunosorbent assay (ELISA) kit. Echocardiography and measurement of CIMT were also conducted. The studied patients were divided according to the median s-Klotho level into 2 groups: patients with low s-Klotho (Group I) and patients with high s-Klotho (Group II).ResultsMean value of s-Klotho was significantly low in HD patients compared to controls (P = 0.001), and mean value of FGF-23 was significantly high in HD patients compared to controls (P = 0.001). The mean values of parathyroid hormone, FGF-23, and phosphorus were significantly high in Group I compared to Group II, whereas the mean value of serum calcium was significantly low in Group I compared to Group II. The mean values of CIMT, LV mass (LVM), LVM index, and LV ejection fraction (LVEF) were high in Group I compared to Group II. Patients with low s-Klotho had significantly more coronary artery disease (CAD). In a regression analysis of s-Klotho with different markers of cardiovascular diseases, s-Klotho showed significant association with CIMT, LVEF, and CAD, but not with LVM and LVM index.ConclusionThe present study showed that patients with a low s-Klotho were more often associated with increased CIMT, LV dysfunction, and CAD, and it seems that there was independent association between s-Klotho and CIMT, LVEF, and CAD.

Segmental mirroring is superior in reflecting the bone anatomy in 3-dimensional models, thus eliminating intraoperative plate readjustment and providing better plate adaptation with better contour. It decreases operating time and costs and thus can be recommended for lesions that do not cross the midline.

Purpose: The intent of the study was to compare the periodontal and bony changes of piezocision corticotomy with bone graft guided by 3D-surgical template in maxillary protrusion versus non grafted one. Patients and Methods: Prospective study included 20 maxillary protrusive female patients with age group ranging between 20 and 50 years. Patients were divided in to group I: treated with piezocision corticotomy without bone graft guided by 3D surgical template. Group II: treated with piezocision corticotomy with bone graft guided by 3D surgical template. CBCT scan was performed of all the patients. Gingival index (GI), probing depth (PD) and CBCT images were performed at baseline and 6months then collected data were analyzed using SPSS statistical analysis program. Results: There were significant reductions in GI, and PD of Group I and Group II from baseline to 3 months. Radiographic analysis of group II showed a statistically significant increase of labial bone thickness (LBT) after 6 months. Conclusion: The uses of guided bone regeneration during cortioctomy improve the clinical parameter and augment the labial bone with minimal loss of bone thickness during en-mass movement.

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