Assessment of the relationship between serum soluble Klotho and carotid intima–media thickness and left ventricular dysfunction in hemodialysis patients

Abdallah, Emad; Mosbah, Osama; Khalifa, Ghada Amin; Metwaly, Amna; El-Bendary, Omnia

doi:10.1016/j.krcp.2015.12.006

Cited by 22 publications

(25 citation statements)

References 41 publications

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“…We studied the correlation between serum klotho levels and both pulmonary hypertension and LVH, and we found that patients with lower serum klotho levels showing a trend toward presence of pulmonary hypertension and LVH. Our findings are in agreement with a recently published study that showed that patients with a low sKlotho were more often associated with increased Carotid intimamedia thickness and LV dysfunction [19] .…”

Section: Discussionsupporting

confidence: 94%

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Study of Serum Soluble Klotho in Egyptian Hemodialysis Patients

Keryakos¹

2017

JMSCR

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Section: Discussionsupporting

confidence: 94%

“…This is consistent with many studies in CKD patients [19,22] Limitations of our study are several. First, the number of evaluated patients is rather low.…”

Section: Discussionsupporting

confidence: 92%

Study of Serum Soluble Klotho in Egyptian Hemodialysis Patients

Keryakos¹

2017

JMSCR

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“…A multivariable linear regression model showed serum Klotho had a significant inverse association with LVMI. But in a more recent cross-sectional study including 88 patients with end-stage renal disease on regular hemodialysis, s-Klotho showed significant association with LVEF, but not with LVM and LVMI [10]. Similarly, Buiten et al [25] also failed to find a relationship between serum s-Klotho and LVMI in 127 dialysis patients.…”

Section: Discussionmentioning

confidence: 99%

“…Kim and his colleagues [9] analyzed 2,101 CKD patients (the mean estimated glomerular filtration rate was 53.0 ± 30.7 mL/min/1.73 m 2 ) and reported that serum Klotho was an independent biomarker of left ventricular mass index (LVMI). But another cross-sectional study with 88 MHD patients showed that s-Klotho was significantly associated with left ventricular ejection fraction (LVEF), but not with LVMI [10]. …”

Section: Introductionmentioning

confidence: 99%

Relationship of Serum Soluble Klotho Levels and Echocardiographic Parameters in Patients on Maintenance Hemodialysis

Zhang

Guo

et al. 2019

Kidney Blood Press Res

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Background: Cardiovascular disease is the leading cause of morbidity and mortality in maintenance hemodialysis (MHD) patients. Uremic cardiomyopathy, characterized by myocardial hypertrophy and fibrosis, has a significant contribution to these adverse cardiac outcomes. The protective effect of soluble Klotho (s-Klotho) on myocardial damage was demonstrated in in vitro and animal experiments. However, data from MHD patients is limited. The present study was designed to identify potential correlations between echocardiographic parameters and serum s-Klotho levels in MHD patients. Methods: This is a cross-sectional study involving 105 MHD patients from the Dialysis Center of Capital Medical University affiliated Beijing Friendship Hospital between March and October 2014. The general information for each patient was recorded. Fasting blood samples were collected prior to hemodialysis during the mid-week session in all patients. The echocardiogram and left lateral lumbar spine radiograph were performed after the same mid-week session. The dialysis records for each session within 3 months before the blood tests were documented. According to the quartiles of s-Klotho levels, patients were divided into four groups (Group 1–4). The demographic and clinical characteristics, echocardiographic parameters, and abdominal aortic calcification scores among the groups were compared. Results: The enrolled 105 patients were predominantly male (54.3%) with an average age of 59.9 ± 11.2 years. Previous hemodialysis durations were 76 (42–133) months. Sixteen (15.2%) patients had diabetes mellitus. Mean serum s-Klotho level was 411.83 ± 152.95 pg/mL, and the 25th percentile, 50th percentile, and 75th percentile values of serum s-Klotho levels were 298.9, 412, and 498.2 pg/mL, respectively. Individuals in the bottom quartile of s-Klotho levels (Group 1) had significantly increased interventricular septal thickness (IVST) compared to those in the other three quartiles of s-Klotho levels (Group 1: 1.12 ± 0.16 cm; vs. Group 2: 1.12 ± 0.16 cm, p = 0.008; vs. Group 3: 0.94 ± 0.13 cm, p < 0.001; vs. Group 4: 1.03 ± 0.1 5 cm, p = 0.022). There were significant differences in the ratios of IVST and posterior wall thickness (PWT) between patients of Group 1 and Group 3 (1.12 ± 0.1 2 vs. 1.00 ± 0.1 4, p = 0.004). No significant differences were found for other parameters among the groups. The univariate correlation analyses showed that gender (r = –0.211, p = 0.030), Kt/V urea (r = –0.240, p = 0.014), hypersensitive C reactive protein (hs-CRP) (r = 0.196, p = 0.045), and serum s-Klotho levels (r = –0.260, p = 0.007) significantly correlated with IVST. Ultimately, only hs-CRP and serum s-Klotho levels were entered into a multiple regression model. Conclusions: The present study showed that patients with lower circulating s-Klotho levels were more often associated with larger IVST and greater ratios of IVST and PWT. There was an independent association between s-Klotho and IVST, and lower s-Klotho levels seem to be a potential risk factor of uremic...

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“…К настоящему времени большинство исследований роли s-Klotho проведено в эксперименте или на попу-ляции лишь для диализных больных [5,6]. У пациентов с додиализными стадиями роль белка s-Klotho изучена значительно хуже.…”

Section: актуальные вопросы внутренних болезней введениеunclassified

Decreased Serum Levels of Klotho Protein in Chronic Kidney Disease Patients: Clinical Imortance

et al. 2016

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Objective: to determine the role of serum Klotho (s-Klotho) protein levels changes in patients with different stages of chronic kidney disease (CKD). Methods: The study involved 130 patients with CKD stages 1-5D (mean age -41±6.7 years). Serum levels of parathyroid hormone (PTH), calcium, phosphorus and s-Klotho protein (ELISA method) at baseline and after 1 year of follow-up were examined in all the

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Assessment of the relationship between serum soluble Klotho and carotid intima–media thickness and left ventricular dysfunction in hemodialysis patients

Cited by 22 publications

References 41 publications

Study of Serum Soluble Klotho in Egyptian Hemodialysis Patients

Study of Serum Soluble Klotho in Egyptian Hemodialysis Patients

Relationship of Serum Soluble Klotho Levels and Echocardiographic Parameters in Patients on Maintenance Hemodialysis

Decreased Serum Levels of Klotho Protein in Chronic Kidney Disease Patients: Clinical Imortance

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