Single 1 mg doses of FTY720 were well tolerated in healthy subjects and elicited a moderate decrease in peripheral blood lymphocyte count and a transient decrease in heart rate consistent with its pharmacological mode of action. FTY720 may be administered without regard to the timing of meals or their fat content.
Octadecyl phosphoric acid ester has been found to produce oriented, well-ordered monolayers on a flat
tantalum(V) oxide surface, via self-assembly from a heptane/propan-2-ol solution. By means of contact
angle, optical waveguide lightmode spectroscopy (OWLS), near-edge X-ray absorption fine structure
spectroscopy (NEXAFS), and X-ray photoelectron spectroscopy (XPS) measurements, it has been shown
that these layers closely resemble those formed by the corresponding thiol−gold system, with respect to
packing density, inclination, and order. The system shows promise as an approach to functionalizing oxide
surfaces with well-ordered organic monolayers, with potential applications in the fields of biochemical
analysis and sensors.
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