It is increasingly recognized that material surface topography is able to evoke specific cellular responses, endowing materials with instructive properties that were formerly reserved for growth factors. This opens the window to improve upon, in a cost-effective manner, biological performance of any surface used in the human body. Unfortunately, the interplay between surface topographies and cell behavior is complex and still incompletely understood. Rational approaches to search for bioactive surfaces will therefore omit previously unperceived interactions. Hence, in the present study, we use mathematical algorithms to design nonbiased, random surface features and produce chips of poly(lactic acid) with 2,176 different topographies. With human mesenchymal stromal cells (hMSCs) grown on the chips and using high-content imaging, we reveal unique, formerly unknown, surface topographies that are able to induce MSC proliferation or osteogenic differentiation. Moreover, we correlate parameters of the mathematical algorithms to cellular responses, which yield novel design criteria for these particular parameters. In conclusion, we demonstrate that randomized libraries of surface topographies can be broadly applied to unravel the interplay between cells and surface topography and to find improved material surfaces.
In an attempt to ensure good-quality printouts of our technical reports, from the supplied PDF files, we process to PDF using Acrobat Distiller. We encourage our authors to use outline fonts coupled with embedding of the used subset of all fonts (in either Truetype or Type 1 formats) except for the standard Acrobat typeface families of Times, Helvetica (Arial), Courier and Symbol. In the case of papers prepared using TEX or LATEX we endeavour to use subsetted AbstractThis paper is concerned with the development of intelligent decision support methodologies for nurse rostering problems in large modern hospital environments. We present an approach which hybridises heuristic ordering with variable neighbourhood search. We show that the search can be extended and the solution quality can be significantly improved by the careful combination and repeated use of heuristic ordering, variable neighbourhood search and backtracking. The amount of computational time that is allowed plays a significant role and we analyse and discuss this. The algorithms are evaluated against a commercial Genetic Algorithm on commercial data. We demonstrate that this methodology can significantly outperform the commercial algorithm. This paper is one of the few in the scientific nurse rostering literature which deal with commercial data and which compare against a commercially implemented algorithms.It is clear that the efficient rostering of healthcare personnel can lead to the more effective utilisation of valuable resources. Healthcare institutions around the world are becoming increasingly interested in the deployment of decision support technology to aid the personnel scheduling process. A very general form of the nurse rostering problem could be described as follows: Given a set of shifts and a set of nurses over a certain time period, assign each shift to a nurse subject to a set of constraints. The constraints are usually defined by regulations, working practices and the preferences of the nurses.The problem of nurse rostering is relatively easily described but like most real world search problems it is far from easy to automatically generate very high quality solutions. Indeed, there have been many papers over the years from across operational research and artificial intelligence that have tackled the problem in one form or another. A wide range of approaches and techniques have been investigated and used. Ernst et al. (2004) identified 28 different categories of methods that have been used on personnel scheduling problems. These include constraint logic programming, constructive heuristic, expert systems, genetic algorithms, integer programming, set partitioning, simple local search and simulated annealing. A recent review of automated nurse rostering approaches found that although there has been a lot of research in the area, surprisingly few of the methods were tested on real world data (Burke et al. 2004). The paper went on to conclude that even fewer have actually been implemented in real hospital wards.Of those techniques tha...
This paper presents a methodology to plan treatments for rehabilitation outpatients. These patients require a series of treatments by therapists from various disciplines. In current practice, when treatments are planned, a lack of coordination between the different disciplines, along with a failure to plan the entire treatment plan at once, often occurs. This situation jeopardizes both the quality of care and the logistical performance.The multidisciplinary nature of the rehabilitation process complicates planning and control. An integral treatment planning methodology, based on an integer linear programming (ILP) formulation, ensures continuity of the rehabilitation process while simultaneously controlling seven performance indicators including access times, combination appointments, and therapist utilization. We apply our approach to the rehabilitation outpatient clinic of the Academic Medical Center (AMC) in Amsterdam, the Netherlands. Based on the results of this case, we are convinced that our approach can be valuable for decision-making support in resource capacity planning and control at many rehabilitation
The High School Timetabling Problem is amongst the most widely used timetabling problems. This problem has varying structures in different high schools even within the same country or educational system. Due to lack of standard benchmarks and data formats this problem has been studied less than other timetabling problems in the literature. In this paper we describe the High School Timetabling Problem in several countries in order to find a common set of constraints and objectives. Our main goal is to provide exchangeable benchmarks for this problem. To achieve this we propose a standard data format suitable for different countries and educational systems, defined by an XML schema. The schema and datasets are available online.
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