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Drug-resistant tuberculosis (DR-TB) remains a major global health problem. Early treatment of TB is critical; in the absence of rapid- susceptibility testing, the empiric selection of drugs should be guided by clinical data. This study aimed to determine the clinical predictors of DR-TB. From September 2010 to August 2017, sociodemographic and clinical characteristics were collected from 144 patients with tuberculosis at the Hospital Civil de Guadalajara, Mexico. Isolates were subjected to drug-susceptibility testing. Clinical predictors of DR-TB were determined using univariate and multivariate analysis. Any drug, isoniazid, and rifampin resistance rates were 47.7, 23.0, and 11.6%, respectively. The visualization of cavities and nodules through either chest radiography or computed tomography were independent predictors of DR-TB. In conclusion, early detection of DR-TB in this population could be based on multiple cavities being observed using chest imaging. This study’s results can be applied to future patients with TB in our community to optimize the DR-TB diagnostic process.

Contribución de los autores:Eduardo Rodríguez-Noriega y Rayo Morfín-Otero: desarrollo del estudio, identificación de referencias, primer borrador del artículo, revisión de la evolución del manuscrito. Gerardo León-Garnica, Santiago Petersen-Morfín, Héctor Raúl Pérez-Gómez, Esteban González-Díaz: revisión de todas las publicaciones y el manuscrito. Eduardo Rodríguez-Noriega: responsable de la totalidad del artículo. Todos los autores revisaron y aprobaron la versión final del manuscrito. REVISIÓN DE TEMA