Ceftaroline fosamil demonstrated high clinical cure and microbiological success rates, was efficacious against cSSSIs caused by MRSA and other common cSSSI pathogens and was generally well tolerated. Monotherapy with ceftaroline fosamil has the potential to provide an alternative treatment for cSSSIs.
Hepatic AEs were more common and response rates lower in HBV/HCV-coinfected patients treated with rilpivirine or efavirenz than in those who were not coinfected.
7‐11 November 2010, Tenth International Congress on Drug Therapy in HIV Infection, Glasgow, UK
ObjectivesThe aim of the study was to translate and validate the ASAS Health Index (ASAS-HI) for Argentinean patients with spondyloarthritis.MethodsTranslation was done using a forward-backward procedure and qualitative interview were done with the translation. Patients fulfilling ASAS classification criteria for either axial (axSpA) or periphereal SpA (pSpA) were included to test psychometric properties. Test-retest reliability was assessed by intraclass correlation coefficient (ICC) in patients without treatment changes (stable disease state). In patients who required therapeutic modifications due to changes of disease activity, responsiveness was evaluated using a standardized response mean (SRM). Construct validity against other health outcomes was evaluated by Spearman correlation. Internal consistency (Cronbach-alfa) and discriminative ability between ASAS-HI and ASDAS were assessed.ResultsTranslation into Argentinean Spanish was accepted with minor changes. Fifty two patients were recruited [65% male, mean (SD) age 39. 5 (12.5) years and median (IQR) disease duration 72 (45–138) months]. Most of the patients had axSpA diagnosis (AS: 26, nr-axSpA: 18) while the rest had pSpA (8). The total score of the ASAS-HI was 7.4 (SD: 4.4), BASDAI: 4.4 (SD: 2.7), BASFI: 4.0 (SD: 3.1), ASDAS-CRP: 2.4 (SD: 0.9). Test-retest reliability (n: 20) was good ICC: 0.88 (95%IC 0.76 to 0.98). Sensitivity to change was tested in 13 patients and SMR was -0.61 for those patients receiving TNF inhibitors (n: 11). Convergent validity ranged as hypothesized with Spearman correlations from low (age: 0.27) to good (pain: 0.65), (table 1). The ASAS-HI discriminated well between patients with different stages of disease activity and function irrespective of the measure applied (ASDAS, BASDAI and BASFI) (table 2). The internal consistency according to Cronbach's alfa was 0.81.Table 1.Spearmen correlation coefficientCharacteristicsSpearmen correlation coefficient ASAS-HI (0–17)p value Age0.27<0.05Pain (0–10)0.65<0.001Night spinal pain (0–10)0.54<0.001ASDAS0.51<0.001BASDAI (0–10)0.60<0.001BASFI (0–10)0.54<0.001SF-36 Total0.46<0.001Table 2.ASDAS Status GroupsASDAS Status Groups Inactive (n: 9)Moderate (n: 9)High (n: 29)very high (n: 5) ASAS-HI (0–17)3.44 (± 3.9)5.77 (± 4.79)9. 06 (± 3.49)10.05 (± 4.5)BASFI (0–10)0,53 (± 0,35)1.41 (± 1.40)5.5 (± 2.46)6.46 (± 3.12)BASDAI (0–10)1.21 (± 0.49)2.37 (± 1.7)5.73 (± 1.91)6.46 (± 3.38)ConclusionsThe Argentinean version of the ASAS-HI was comprehensive and reliable by patients with SpA. The ASAS-HI is a valid tool for assessing overall functioning and health in spondyloarthritis.References The ASAS Health Index (ASAS HI)a new tool to assess the health status of patients with spondyloarthritis, Clin Exp Rheumatol 2014;32:S105-S108. Disclosure of InterestV. Duarte Employee of: Novartis Argentina, U. Kiltz: None declared, V. Navarro-Compán: None declared, N. Lloves: None declared, G. Crespo Amaya: None declared, L. Ferreyra: None declared, C. Orozco: None declared, E. Schneeberger: None declared, H. Mald...
BackgroundThe Duruöz Hand Index (DIH) is a reliable tool for the evaluation of hand's function in patients with scleroderma.ObjectivesThe aim of our study was to adapt and to validate the DHI questionnaire in an Argentinian population with scleroderma.MethodsFor validation, 3 rheumatologists adapted and translated to Spanish the original version in French and the final version was re-translated to French by a bilingual person. To evaluate the construct validity, we used the patient global visual analogue scale (VAS), VAS for questions for the same activity, the health assessment questionnaire (HAQ) and the Rodnan. A subsample attended a second visit to evaluate reproducibility, with no modifications in the treatment in relation to the previous visit. Continuos variables were expressed as mean and standard desviation (SD) or medians with their interquartile range (IQR). Spearman's correlation coefficient was used to quantify the degree of correlation between the different VAS, HAQ and Rodnan with the total score. The intraclass correlation coefficient (ICC) was used to assess reproducibility and Cronbach's alpha to evaluate internal consistency.Results45 patients diagnosed with scleroderma were included in the study. 84,44% were women, mean age of 51±13,72 years (SD), 48,89% were Mestizos, while 46,67% were Caucasians with a disease duration of 24 months (IQR: 18-60). 64, 44% patients had diagnostic of limited scleroderma; 77, 78% were right handed and 53, 33% had extra cutaneous manifestations. Raynaud was present in 93, 33%, pitting scars in 33, 33% and digital ulcers in 26, 67%. The median score of the total questionnaire was 4, 5 (IQR: 0-26), of the global VAS 49 (IQR: 10-50), of HAQ 0,3 (IQR: 0-1) and of Rodnan 5 (IQR:2-11). The correlation between the total score of DHI and the patient global VAS was 0, 58, with the HAQ was 0, 63 and with Rodnan 0, 08. The correlation coefficient between the VAS and each group of questions for the same activity in the DHI questionnaire, indicated good correlation for the questions that refer to activities of kitchen(0,60;0,71;0,67;0,67;0,59;0,62;0,55), as well as for dressing(0,69;0,65;057), for hygiene (0,61;0,56), and for the office questions (o,56;0,73). There was excellent level of correlation with those related to fine motor activities with a maximun r value of 0, 78. The reproducibility was 0, 88 (CI 95% 0,76-0,99) and the internal consistency according to Cronbach's alpha was 0,98.ConclusionsThe results from this study show the DHI to be a reliable and valid test for this Argentinian population with scleroderma.ReferencesDuruoz MT, Poiraudeau S, Fermanian J, Menkes C, Amor B, Dougados M, et al. Development and validation of a rheumatoid Duruoz's Hand Index that assesses functional handicap. J Rheumatol 1996; 23:1167–72.AcknowledgementsJanet L. Poole.Disclosure of InterestNone declared
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