SAT0427 Asas health index: validity and reliability in argentinean patients with spondyloarthritis

Abstract

ObjectivesThe aim of the study was to translate and validate the ASAS Health Index (ASAS-HI) for Argentinean patients with spondyloarthritis.MethodsTranslation was done using a forward-backward procedure and qualitative interview were done with the translation. Patients fulfilling ASAS classification criteria for either axial (axSpA) or periphereal SpA (pSpA) were included to test psychometric properties. Test-retest reliability was assessed by intraclass correlation coefficient (ICC) in patients without treatment changes (stable disease state). In patients who required therapeutic modifications due to changes of disease activity, responsiveness was evaluated using a standardized response mean (SRM). Construct validity against other health outcomes was evaluated by Spearman correlation. Internal consistency (Cronbach-alfa) and discriminative ability between ASAS-HI and ASDAS were assessed.ResultsTranslation into Argentinean Spanish was accepted with minor changes. Fifty two patients were recruited [65% male, mean (SD) age 39. 5 (12.5) years and median (IQR) disease duration 72 (45–138) months]. Most of the patients had axSpA diagnosis (AS: 26, nr-axSpA: 18) while the rest had pSpA (8). The total score of the ASAS-HI was 7.4 (SD: 4.4), BASDAI: 4.4 (SD: 2.7), BASFI: 4.0 (SD: 3.1), ASDAS-CRP: 2.4 (SD: 0.9). Test-retest reliability (n: 20) was good ICC: 0.88 (95%IC 0.76 to 0.98). Sensitivity to change was tested in 13 patients and SMR was -0.61 for those patients receiving TNF inhibitors (n: 11). Convergent validity ranged as hypothesized with Spearman correlations from low (age: 0.27) to good (pain: 0.65), (table 1). The ASAS-HI discriminated well between patients with different stages of disease activity and function irrespective of the measure applied (ASDAS, BASDAI and BASFI) (table 2). The internal consistency according to Cronbach's alfa was 0.81.Table 1.Spearmen correlation coefficientCharacteristicsSpearmen correlation coefficient ASAS-HI (0–17)p value Age0.27<0.05Pain (0–10)0.65<0.001Night spinal pain (0–10)0.54<0.001ASDAS0.51<0.001BASDAI (0–10)0.60<0.001BASFI (0–10)0.54<0.001SF-36 Total0.46<0.001Table 2.ASDAS Status GroupsASDAS Status Groups Inactive (n: 9)Moderate (n: 9)High (n: 29)very high (n: 5) ASAS-HI (0–17)3.44 (± 3.9)5.77 (± 4.79)9. 06 (± 3.49)10.05 (± 4.5)BASFI (0–10)0,53 (± 0,35)1.41 (± 1.40)5.5 (± 2.46)6.46 (± 3.12)BASDAI (0–10)1.21 (± 0.49)2.37 (± 1.7)5.73 (± 1.91)6.46 (± 3.38)ConclusionsThe Argentinean version of the ASAS-HI was comprehensive and reliable by patients with SpA. The ASAS-HI is a valid tool for assessing overall functioning and health in spondyloarthritis.References The ASAS Health Index (ASAS HI)a new tool to assess the health status of patients with spondyloarthritis, Clin Exp Rheumatol 2014;32:S105-S108. Disclosure of InterestV. Duarte Employee of: Novartis Argentina, U. Kiltz: None declared, V. Navarro-Compán: None declared, N. Lloves: None declared, G. Crespo Amaya: None declared, L. Ferreyra: None declared, C. Orozco: None declared, E. Schneeberger: None declared, H. Mald...

ASAS Health Index performance in real-life Spondyloarthritis patients

“…En todos los pacientes incluidos se evaluó la versión en español validada en Argentina del ASAS-HI. 12 El resultado del ASAS-HI (0-17) fue categorizado, según puntos de corte del grupo ASAS, de la siguiente manera: ≤5 puntos: buen estado de salud, 5-12 puntos: moderado estado de salud y ≥12 puntos: pobre estado de 9 -15 Mail de contacto: martirevictoria@gmail.com salud). 2 En pacientes con EspAp se administró el cuestionario Health Assessment Questionnaire (HAQ) y evaluación de sitios de entesitis según Leeds Enthesitis Index (LEI).…”

“…[9][10][11] Este cuestionario fue validado en Argentina en el año 2017. 12 Por otro lado, fue escasamente evaluado de manera independiente en pacientes con EspAp. 13 Conociendo los pocos reportes del uso de este cuestionario en pacientes de la vida diaria y en pacientes con EspAp nos propusimos evaluar el rendimiento del ASAS-HI en pacientes con EspA tanto axial como periférica de la práctica clínica habitual en centros de Argentina, evaluar su validez de constructo y determinar los factores asociados al pobre estado de salud.…”