Serum prolactin levels rise after generalized tonic-clonic and partial complex seizures, but not after pseudoepileptic seizures. The criteria for a significant elevation in serum prolactin vary with individual investigators. The prevalence of pseudoseizures in the population studied determines the predictive value of serum prolactin determinations. In populations where most patients have epilepsy, a rise in serum prolactin is highly predictive for true epilepsy, but no increase in serum prolactin is not predictive for pseudoseizures.

The Planet Formation Imager (PFI) project aims to image the period of planet assembly directly, resolving structures as small as a giant planet's Hill sphere. These images will be required in order to determine the key mechanisms for planet formation at the time when processes of grain growth, protoplanet assembly, magnetic fields, disk/planet dynamical interactions and complex radiative transfer all interact -making some planetary systems habitable and others inhospitable. We will present the overall vision for the PFI concept, focusing on the key technologies and requirements that are needed to achieve the science goals. Based on these key requirements, we will define a cost envelope range for the design and highlight where the largest uncertainties lie at this conceptual stage.

Among the most fascinating and hotly-debated areas in contemporary astrophysics are the means by which planetary systems are assembled from the large rotating disks of gas and dust which attend a stellar birth. Although important work has already been, and is still being done both in theory and observation, a full understanding of the physics of planet formation can only be achieved by opening observational windows able to directly witness the process in action. The key requirement is then to probe planet-forming systems at the natural spatial scales over which material is being assembled. By definition, this is the so-called Hill Sphere which delineates the region of influence of a gravitating body within its surrounding environment.The Planet Formation Imager project (PFI; http://www.planetformationimager.org) has crystallized around this challenging goal: to deliver resolved images of Hill-Sphere-sized structures within candidate planethosting disks in the nearest star-forming regions.In this contribution we outline the primary science case of PFI. For this purpose, we briefly review our knowledge about the planet-formation process and discuss recent observational results that have been obtained on the class of transition disks. Spectro-photometric and multi-wavelength interferometric studies of these systems revealed the presence of extended gaps and complex density inhomogeneities that might be triggered by orbiting planets. We present detailed 3-D radiation-hydrodynamic simulations of disks with single and multiple * Copyright 2014 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. DOI abstract: http://dx.doi. org/10.1117/12.2055544 Further author information: Send correspondence to S.K., E-mail: skraus@astro.ex.ac.uk, Telephone: +44 1392 724125 arXiv:1407.7033v1 [astro-ph.IM] 25 Jul 2014 embedded planets, from which we compute synthetic images at near-infrared, mid-infrared, far-infrared, and sub-millimeter wavelengths, enabling a direct comparison of the signatures that are detectable with PFI and complementary facilities such as ALMA. From these simulations, we derive some preliminary specifications that will guide the array design and technology roadmap of the facility.

Complex non-linear and dynamic processes lie at the heart of the planet formation process. Through numerical simulation and basic observational constraints, the basics of planet formation are now coming into focus. High resolution imaging at a range of wavelengths will give us a glimpse into the past of our own solar system and enable a robust theoretical framework for predicting planetary system architectures around a range of stars surrounded by disks with a diversity of initial conditions. Only long-baseline interferometry can provide the needed angular resolution and wavelength coverage to reach these goals and from here we launch our planning efforts. The aim of the "Planet Formation Imager" (PFI) project is to develop the roadmap for the construction of a new near-/mid-infrared interferometric facility that will be optimized to unmask all the major stages of planet formation, from initial dust coagulation, gap formation, evolution of transition disks, mass accretion onto planetary embryos, and eventual disk dispersal. PFI will be able to detect the emission of the cooling, newlyformed planets themselves over the first 100 Myrs, opening up both spectral investigations and also providing a vibrant look into the early dynamical histories of planetary architectures.Here we introduce the Planet Formation Imager (PFI) Project (www.planetformationimager.org) and give initial thoughts on possible facility architectures and technical advances that will be needed to meet the challenging top-level science requirements.