Computational microRNA (miRNA) target prediction is one of the key means for deciphering the role of miRNAs in development and disease. Here, we present the DIANA-microT web server as the user interface to the DIANA-microT 3.0 miRNA target prediction algorithm. The web server provides extensive information for predicted miRNA:target gene interactions with a user-friendly interface, providing extensive connectivity to online biological resources. Target gene and miRNA functions may be elucidated through automated bibliographic searches and functional information is accessible through Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. The web server offers links to nomenclature, sequence and protein databases, and users are facilitated by being able to search for targeted genes using different nomenclatures or functional features, such as the genes possible involvement in biological pathways. The target prediction algorithm supports parameters calculated individually for each miRNA:target gene interaction and provides a signal-to-noise ratio and a precision score that helps in the evaluation of the significance of the predicted results. Using a set of miRNA targets recently identified through the pSILAC method, the performance of several computational target prediction programs was assessed. DIANA-microT 3.0 achieved there with 66% the highest ratio of correctly predicted targets over all predicted targets. The DIANA-microT web server is freely available at www.microrna.gr/microT.

Previous research work has identified memory bandwidth as the main bottleneck of the ubiquitous Sparse Matrix-Vector Multiplication kernel. To attack this problem, we aim at reducing the overall data volume of the algorithm. Typical sparse matrix representation schemes store only the nonzero elements of the matrix and employ additional indexing information to properly iterate over these elements. In this paper we propose two distinct compression methods targeting index and numerical values respectively. We perform a set of experiments on a large real-world matrix set and demonstrate that the index compression method can be applied successfully to a wide range of matrices. Moreover, the value compression method is able to achieve impressive speedups in a more limited yet important class of sparse matrices that contain a small number of distinct values.

In this paper we revisit the performance issues of the widely used sparse matrix-vector multiplication (SpMxV) kernel on modern microarchitectures. Previous scientific work reports a number of different factors that may significantly reduce performance. However, the interaction of these factors with the underlying architectural characteristics is not clearly understood, a fact that may lead to misguided and thus unsuccessful attempts for optimization. In order to gain an insight on the details of SpMxV performance, we conduct a suite of experiments on a rich set of matrices for three different commodity hardware platforms. Based on our experiments we extract useful conclusions that can serve as guidelines for the subsequent optimization process of the kernel.

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