Contrast-induced acute kidney injury (CI-AKI) is a serious complication after angiographic examinations in cardiology. Diagnosis may be delayed based on standard serum creatinine, and subclinical forms of kidney damage may not be detected at all. In our study, we investigate the clinical use in these directions of a “damage”-type biomarker—neutrophil gelatinase-associated lipocalin (NGAL). Among patients with a high-risk profile undergoing scheduled coronary angiography and/or angioplasty, plasma NGAL was determined at baseline and at 4th and 24th h after contrast administration. In the CI-AKI group, NGAL increased significantly at the 4th hour (Me 109.3 (IQR 92.1–148.7) ng/mL versus 97.6 (IQR 69.4–127.0) ng/mL, p = 0.006) and at the 24th hour (Me 131.0 (IQR 81.1–240.8) ng/mL, p = 0.008). In patients with subclinical CI-AKI, NGAL also increased significantly at the 4th hour (Me 94.0 (IQR 75.5–148.2) ng/mL, p = 0.002) and reached levels close to those in patients with CI-AKI. Unlike the new biomarker, however, serum creatinine did not change significantly in this group. The diagnostic power of NGAL is extremely good—AUC 0.847 (95% CI: 0.677–1.000; p = 0.001) in CI-AKI and AUC 0.731 (95% CI: 0.539–0.924; p = 0.024) in subclinical CI-AKI. NGAL may be a reliable biomarker for the early diagnosis of clinical and subclinical forms of renal injury after contrast angiographic studies.
Contrast-induced acute kidney injury (CI-AKI) is a serious complication after angiographic examinations in cardiology. Diagnosis may be delayed based on standard serum creatinine, and subclinical forms of kidney damage may not be detected at all. In our study we investigate the clinical use in these directions of a “damage” type biomarker - Neutrophil Gelatinase-Associated Lipocalin (NGAL). Among patients with a high-risk profile undergoing scheduled coronary angiography and/or angioplasty, plasmsa NGAL was determined at baseline, at 4 and 24 hours after contrast administration. In the CI-AKI group, NGAL increased significantly at the 4th hour (132.33±72.83 ng/ml versus 111.48±65.06 ng/ml, p=0.006) and at the 24th hour (212 .93±276.61 ng/ml, p=0.008). In patients with subclinical CI-AKI, NGAL also increased significantly at the 4th hour (128.18±99 ng/ml, p=0.002) and reached levels close to those in patients with CI-AKI. Unlike new biomarker, however, serum creatinine did not change significantly in this group. The diagnostic power of NGAL is extremely good - AUC 0.847 (95% CI: 0.677-1.000; p=0.001) in CI-AKI and AUC 0.731 (95% CI: 0.539 – 0.924; p=0.024) in subclinical CI-AKI. NGAL may be a reliable biomarker for early diagnosis of clinical and subclinical forms of renal injury after contrast angiographic studies.
Издательство «Фəн» Казань, Татарстан Главный редактор Член-корреспондент АН РТ Ф.Ш. Хузин Заместители главного редактора: доктор исторических наук А.Г. Ситдиков доктор исторических наук Ю.А. Зеленеев Ответственный секретарь-кандидат ветеринарных наук Г.Ш. Асылгараева Редакционный совет: Р.С. Хакимоввице-президент АН РТ (Казань, Россия) (председатель) Х.А. Амирхановчлен-корреспондент РАН, доктор исторических наук, профессор (Махачкала, Россия) И. Бальдауфдоктор наук, профессор (Берлин, Германия) П. Георгиевдоктор наук, доцент (Шумен, Болгария) Е.П. Казаковдоктор исторических наук (Казань, Россия) Н.Н. Крадинчлен-корреспондент РАН, доктор исторических наук, профессор (Владивосток, Россия) А. Тюрк-PhD (Будапешт, Венгрия) И. Фодордоктор исторических наук, профессор (Будапешт, Венгрия) В.Л. Янинакадемик РАН, доктор исторических наук профессор (Москва, Россия) Редакционная коллегия: А.А. Выборнов-доктор исторических наук, профессор (Самара, Россия) М.Ш. Галимова-кандидат исторических наук (Казань, Россия) Р.Д. Голдина-доктор исторических наук, профессор (Ижевск, Россия) И.Л. Измайлов-кандидат исторических наук (Казань, Россия) С.В. Кузьминых-кандидат исторических наук (Москва, Россия) А.Е. Леонтьев-доктор исторических наук (Москва, Россия) Т.Б. Никитина-доктор исторических наук (Йошкар-Ола, Россия) Ответственный за выпуск: Б.Л. Хамидуллинкандидат исторических наук (Казань, Россия)
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