The clinical manifestations of this hydroxychloroquine overdose were similar to those reported for chloroquine overdose and the management principles recommended for chloroquine overdose appeared to be efficacious in this case.

fig. 1). He had no other symptoms until carotid sinus massage was applied, when he suddenly collapsed, pulseless; the tachycardia continued at a faster rate, resisted cardioversion and degenerated into frank fibrillation 40 minutes after its onset. Asystole occurred 3 minutes later. The recording made before cardiac arrest showed frequent multiform VECs, some in dimorphic couplets ( fig. 1). The T-wave inversion became pronounced before ventricular tachycardia initiated by an R-on-T VEC in the wake of a postextrasystolic pause. The autopsy showed left ventricular hypertrophy and extensive recent anterior infarction. This 83-year-old white man was admitted for recurrent colonic bleeding. The physical examination showed mild left-sided weakness, a grade 3/6 aortic systolic murmur and a blood pressure of 150/100 mm Hg. He subsequently had episodes of cyanosis, unresponsiveness and restlessness. During one of them, he was apneic in his chair, apparently pulseless; immediately afterwards he became alert, with a heart rate of 100 beats/min and a blood pressure of 190/100 mm Hg. The ECGs, unchanged from the previous year, showed left ventricular hypertrophy and ST-T-wave

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Summary: A case of acute left ventricular failure following an intravenous dose of amphetamine is described. The diagnosis was made by right heart catheterization. This is the first description of acute amphetamine cardiomyopathy in the medical literature.

ABSTRACT. Three‐year‐old girl with eight month history of convulsive syncope due to complete heart block, prolonged QT interval and paroxysms of ventricular tachycardia is described. An episode of torsade de pointes tachycardia followed by asystole was documented. The symptoms and electrocardiographic abnormalities were controlled by pacemaker therapy. The subset of “congenital heart block'’patients with prolonged QT interval is at high risk of sudden death and should be regarded as a previously unrecognized form of Romano‐Ward syndrome.