Acute amphetamine cardiomyopathy in a drug addict

O'Neill, M E; Arnolda, Leonard F; Coles, David M.; Nikolić, George

doi:10.1002/clc.4960060407

Cited by 25 publications

(5 citation statements)

References 7 publications

(7 reference statements)

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“…Since single doses of PPA that cause myocardial necrosis in rats are comparable to doses that have caused such injury in humans, this animal model likely has clinical relevance with respect to the pattern of toxicity manifested in humans (9). It is also noteworthy that a similar microscopic myocardial injury pattern has been described for patients with pheochromocytoma and amphetamine-associated cardiomyopathy (12,14,15).…”

Section: Phentolamine Reduces Myocardial Injury and Mortality 133mentioning

confidence: 84%

Phentolamine Reduces Myocardial Injury and Mortality in a Rat Model of Phenylpropanolamine Poisoning

Burns

Dickson

Sivilotti

et al. 2001

Journal of Toxicology: Clinical Toxicology

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Section: Phentolamine Reduces Myocardial Injury and Mortality 133mentioning

confidence: 84%

Phentolamine Reduces Myocardial Injury and Mortality in a Rat Model of Phenylpropanolamine Poisoning

Burns

Dickson

Sivilotti

et al. 2001

Journal of Toxicology: Clinical Toxicology

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“…On at least one occasion the degree of left ventricular failure was severe enough to lead to death despite therapy [1]. Several authors report acute reversible left ventricular function following intravenous administration which is a common route of abuse along with smoking or ingesting the drug [3, 4]. Fortunately our patient was not taking amphetamines during either of her pregnancies, as prenatal exposure has also been associated with cardiomyopathy in the neonate [5].…”

Section: Discussionmentioning

confidence: 99%

‘Ally McBeal heart?’– Drug induced cardiomyopathy in a young woman

Crean¹,

Pohl²

2004

Brit J Clinical Pharma

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Dilated cardiomyopathy is relatively uncommon in women of child bearing age. When it does occur, it is most commonly as a sequela of pregnancy, viral myocarditis or excessive alcohol intake. However, individuals in this age group are also amongst the most likely to consume other recreational drugs. We present the case of a young woman whose long-term amphetamine habit resulted in severe impairment of left ventricular function.Mrs X was a 30-year-old mother of two children who was referred from her general practitioner with a four month history of ankle swelling, together with increased abdominal distension and breathlessness over the previous 3 days. Past medical history included an episode of pneumonia 7 years earlier, mild asthma (never requiring hospitalization), and regular panic attacks.Symptomatic enquiry revealed that she had been experiencing a sensation of panic most nights in the last 2 months when she found she had been waking from sleep breathless. These symptoms were eased by sitting forward and she was adamant that they were quite distinct from the symptoms she would typically experience during a traditional panic attack.She had a 20-pack year smoking history but professed only very occasional alcohol consumption. She did, however, admit to having taken amphetamines on a daily basis for the last 4 years. Her motivation for this habit was a desire to stay thin -and indeed she had initially begun to abuse the drug at a time when she was trying to give up smoking and subsequently gained weight. She purchased the drug illegally, consuming approximately one tablespoon per day. She estimated that she would utilize 15 g of amphetamine per month at a price of roughly 10 pounds sterling per gram.On examination she was thin with a BMI of 19 kg m -2 . Respiratory rate was increased and saturations on air were low at 92%. A sinus tachycardia of 120 bpm was present. Blood pressure was 125/90. The apex beat was displaced and the jugular venous pressure was elevated 8 cm. Auscultation revealed a gallop rhythm and a left basal effusion. There was hepatomegaly, mild ascites and peripheral pitting oedema.ECG demonstrated biphasic P waves in keeping with left atrial enlargement, a left ventricular hypertrophy and strain pattern, and Q waves in the anteroseptal leads. CXR showed cardiomegaly, interstitial pulmonary oedema and a small left pleural effusion.

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“…It was proposed that khat chewing can affect the heart leading to acute cardiomyopathy [19,[24][25][26]. This suggestion was…”

Section: Heart Failure and Cardiomyopathiesmentioning

confidence: 99%

“…based on few reports which described the occurrence of acute cardiomyopathy secondary to intravenous amphetamine abuse [24,25], and on one study conducted in Yemen, which involved 50 Yemeni patients with dilated cardiomyopathy who were regular khat chewers. The histopathological study of the heart muscle showed myocyte hypertrophy and interstitial fibrosis [19,26].…”

Section: Vol 1 | Issue 2 | Jul -Dec 2022mentioning

confidence: 99%

Khat (Catha edulis) as a risk factor for cardiovascular disorders: Controversies and facts

Aleemallah¹

2022

YJM

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The leaves of khat (Catha edulis) are chewed as a social habit for the central stimulant action of their cathinone content. There is growing concern about the health hazards of chronic khat chewing. Many authors have addressed the adverse effects of khat chewing on the cardiovascular and other systems. Based on a limited number of case reports and few prospective controlled studies, associations between khat chewing and the occurrence of myocardial infarction, dilated cardiomyopathy, and vascular diseases such as hypertension and cerebrovascular ischemia have been proposed. This review outlines the current knowledge on the adverse health effects of khat chewing on the cardiovascular system, assesses the strength and the limitations of the studies, and identifies the questions that the future studies should address.

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Acute amphetamine cardiomyopathy in a drug addict

Abstract: Summary: A case of acute left ventricular failure following an intravenous dose of amphetamine is described. The diagnosis was made by right heart catheterization. This is the first description of acute amphetamine cardiomyopathy in the medical literature.

Cited by 25 publications

References 7 publications

Phentolamine Reduces Myocardial Injury and Mortality in a Rat Model of Phenylpropanolamine Poisoning

Phentolamine Reduces Myocardial Injury and Mortality in a Rat Model of Phenylpropanolamine Poisoning

‘Ally McBeal heart?’– Drug induced cardiomyopathy in a young woman

Khat (Catha edulis) as a risk factor for cardiovascular disorders: Controversies and facts

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