Demineralized dentin, hydroxylapatite, or dentin chips were condensed into the apical 2 mm of canals with perforated apexes in 36 anterior teeth of 8 adult cynomolgus monkeys. The coronal sections of the canals were then obturated with gutta percha and Grossman's sealer. Twelve additional canals with perforated apexes were obturated 2 mm short of their radiographic apexes and served as controls. The amount of hard tissue formation and the degree of inflammation were evaluated after 3 and after 6 months. No differences were noted between the various materials after 3 months. However, after 6 months the samples with apical plugs of hydroxylapatite had more hard tissue formation and less inflammation than the others.
Because of the critical role of nutrition in developmental events, effects of nutritional excesses and deficiencies may be more significant than would be predicted by a steady-state model. Dietary choice is as important in oral health as it is to the health of the entire body, thus it may ultimately serve not only to prevent, but also to treat certain oral diseases.
Leukotrienes play an important role in inflammation and its sequelae such as pain, swelling, and bone resorption. This review covers, their history, structure, synthesis, metabolism, biological effects, inhibitors, antagonists, and their possible role in pathogenesis of pulpal and periapical disease.
An experiment inducing rickets in chicks and correlating the disease to a reduction in vitamin D-dependent calcium binding protein demonstrates hormone induction, protein isolation, and radioisotope methodology.
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