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A traditional Chinese herbal medicine, Kampo medicine, maoto, has been widely used in the treatment of febrile symptoms caused by viral infection. This herbal extract granule for oral use, however, is not well accepted by infants or young children due to its unpleasant taste and odor. Therefore, we prepared Kampo medicine, maoto, suppository and investigated the pharmaceutical and clinical e‹cacy of the suppository. Kampo medicine, maoto, granules were micropulverized and homogeneously dispersed into Hosco-H15 to prepare suppositories containing 0.25 to 1.0 g herbal extract by the conventional fusion method. Content of l-ephedrine, an index compound of Kampo medicine, maoto, in the extract granules and suppositories was determined by using a high performance liquid chromatographic method. Physicochemical experiments revealed that the suppository containing 0.5 g herbal extract had the most suitable melting point of 34°C. Contents of l-ephedrine in the suppository were constant, 93 96％ of those in the same amount of the extract granules in diŠerent three lots. Upper and lower portions of the suppository had the same content of l-ephedrine. The suppository maintained more than 95％ of l-ephedrine content through 6 months at 4°C, room temperature and 40°C, although maldistribution of the extract constituent was observed after storage at 40°C. The suppository was administered to 21 pediatric febrile patients at a dose of 1/3 to 2 full pieces depending on their body weight and physical status. Signiˆcant reduction ( p＜0.001) of body temperature from 39.5 to 37.5°C without serious adverse eŠects was observed in 17 patients who were monitored the clinical eŠects on the febrile symptoms. In conclusion, Kampo medicine, maoto, suppository was found to satisfy the physicochemical quality and quantity standards as well as to be clinically applicable to neonates, infants and children with viral febrile symptoms without any adverse eŠects.

A 900MHz Low Noise Amplifier (LNA) has been developed using 0 . 3 5~~1 standard CMOS technology. MA-MOS (MeshArrayed MOSFET) is introduced for excellent high-frequency performance without salicide technology. The substrate power loss was analyzed and minimized by reducing parasitic elements for a low-noise and low-power operation. As a result, the LNA realized a minimum noise figure (NFmin) of 1.8dB, a forward gain of 14.8dB and IIp3 of-2.5dBm with a low-power consumption of only 9mW from a 3V power supply.

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