Cytokinesis terminates mitosis, resulting in separation of the two sister cells. Septins, a conserved family of GTP-binding cytoskeletal proteins, are an absolute requirement for cytokinesis in budding yeast. We demonstrate that septin-dependence of mammalian cytokinesis differs greatly between cell types: genetic loss of the pivotal septin subunit SEPT7 in vivo reveals that septins are indispensable for cytokinesis in fibroblasts, but expendable in cells of the hematopoietic system. SEPT7-deficient mouse embryos fail to gastrulate, and septin-deficient fibroblasts exhibit pleiotropic defects in the major cytokinetic machinery, including hyperacetylation/stabilization of microtubules and stalled midbody abscission, leading to constitutive multinucleation. We identified the microtubule depolymerizing protein stathmin as a key molecule aiding in septin-independent cytokinesis, demonstrated that stathmin supplementation is sufficient to override cytokinesis failure in SEPT7-null fibroblasts, and that knockdown of stathmin makes proliferation of a hematopoietic cell line sensitive to the septin inhibitor forchlorfenuron. Identification of septin-independent cytokinesis in the hematopoietic system could serve as a key to identify solid tumor-specific molecular targets for inhibition of cell proliferation.

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We report three patients with a cerebrovascular accident studied serially by MRI, including diffusion-weighted imaging (DWI). In case 1, DWI 1 day after the onset of left frontoparietal cortical infarcts showed no abnormal signal in the left corticospinal tract. DWI 12 days after onset showed high signal in the corticospinal tract, interpreted as early wallerian degeneration. This had disappeared by 22 days after onset. In case 2, DWI obtained 7 days after the onset of a right internal capsule lacunar infarct showed high signal from the right corticospinal tract in the brainstem, which was less marked 15 days after onset. In case 3, MRI on postnatal day 7 showed a cerebral haemorrhage in the right corona radiata and high signal from the right corticospinal tract on DWI. The latter disappeared by day 23. DWI shows early wallerian degeneration; transient signal abnormalities within 2 weeks of stroke should not be mistaken for new ischaemic lesions.

A tunable ultraviolet (UV) laser was used to irradiate the screen-printed carbon nanotube (CNT) samples in air and in high vacuum. UV laser lights with wavelengths of 349 and 266 nm from a tunable laser were used with average energy densities of 20.3, 10.2, and 2.25 mJ/cm2, respectively, with different irradiation times. The field emission characteristics of the CNT cathodes irradiated in air were drastically improved, whereas those of the samples irradiated in vacuum were slightly improved. Irradiation by a 266 nm laser light resulted in more obvious improvement in the emission characteristics than that by 349 nm. The maximum emission current density at an applied electric field of 6.2 V /μm at an energy density of 20.3 mJ/cm2 increased from 0.006 to 20.15 mA/cm2 after laser irradiation with a wavelength of 266 nn, and the turn-on field decreased from 3.7 to 1.2 V/μm.

We show that the 3D charged Banados-Teitelboim-Zanelli (BTZ) black hole solution interpolates between two different 2D AdS spacetimes: a near-extremal, nearhorizon AdS 2 geometry with constant dilaton and U(1) field and an asymptotic AdS 2 geometry with a linear dilaton. Thus, the charged BTZ black hole can be considered as interpolating between the two different formulations proposed until now for AdS 2 quantum gravity. In both cases the theory is the chiral half of a 2D CFT and describes, respectively, Brown-Hennaux-like boundary deformations and near-horizon excitations. The central charge c as of the asymptotic CFT is determined by 3D Newton constant G and the AdS length l, c as = 3l/G, whereas that of the near-horizon CFT also depends on the U(1) charge Q, c nh ∝ lQ/ √ G.