No abstract

Purpose -The purpose of this paper is to develop a benchmark of performance standards for Chinese third-party logistics providers (3PLs) in the emerging market. It also intends to identify various factors that significantly affect the operational efficiency of the Chinese 3PLs and propose ways to improve the competitiveness of 3PLs. Design/methodology/approach -This paper proposes data envelopment analysis (DEA) to measure the operational efficiency of ten leading 3PLs in China, relative to prior periods and their key competitors. In particular, this paper develops both the Charnes, Cooper and Rhodes model and the Banker, Charnes and Cooper model that are designed to derive weights without being fixed in advance. It also uses step-wise regression analysis to identify factors influencing the performances of Chinese 3PLs. Findings -First, the declining efficiency within some Chinese 3PLs coincides with a steep decline in domestic transportation activities due to the SARS outbreak and the slow adaptation of state-owned enterprise into a more market-based economy. Second, the sales opportunity and the level of technical expertise are directly correlated with the operational efficiency of 3PLs, whereas the size of 3PLs has no direct bearing on the 3PL's performance. Third, in contrast with the 3PL industry in the USA, the Chinese 3PLs tend to focus on traditional service offerings such as port management, transportation, and warehousing rather than playing the role as the integrator or the lead service provider. Originality/value -This paper is the first attempt to utilize DEA to develop performance benchmarks for 3PLs in the emerging foreign market. The proposed DEA can be easily modified or extended to similar settings in other Asian countries such as India and East European countries.

No abstract

No abstract

The overall prevalence of gastroschisis in China did not change remarkably during 1996 to 2007; but the prevalence of gastroschisis significantly increased among infants whose mothers were 20 to 24 years old and decreased among infants whose mothers were 30 to 34 years old.

Giant hepatic hemangioma is a benign liver condition that may be treated using surgery. We studied the digital subtraction angiographic (DSA) characteristics of giant hepatic hemangioma, and the effectiveness of transcatheter arterial embolization (TAE) alone for its treatment. This was a retrospective study of 27 patients diagnosed with giant hepatic hemangioma and treated with TAE alone (using lipiodol mixed with pingyangmycin) at the Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University, between January 2010 and March 2013. The feeding arteries were identified using DSA. All patients were followed up for between three weeks and 12 months. Changes in tumor diameter and symptoms were observed. The 27 patients included had giant hepatic hemangiomas ranging from 5.3 to 24.5 cm (mean, 11.24±5.08 cm) in the right (n = 13), left (n = 1) or both (n = 13) lobes. Preoperative hepatic angiography showed multiple abnormal vascular lakes in the early phase, known as the “early leaving but late returning, hanging nut on a twig” sign. On the day after TAE, hepatic transaminase levels were increased (ALT: 22.69±17.95 to 94.88±210.32 U/L; ALT: 24.00±12.37 to 99.70±211.54 U/L; both P<0.05), but not total bilirubin. Six patients complained of abdominal pain, and 12 experienced transient fever. In the months after TAE, tumor size decreased (baseline: 11.24±5.08; 3 months: 8.95±4.33; 6 months: 7.60±3.90 cm; P<0.05), and the patients’ condition improved. These results indicated that TAE was effective and safe for treating giant hepatic hemangioma. TAE may be a useful alternative to surgery for the treatment of hepatic hemangioma.

No abstract

BackgroundBreast cancer is the leading cause of oncological mortality among women. Efficient detection of cancer cells in an early stage and potent therapeutic agents targeting metastatic tumors are highly needed to improve survival rates. Emerging evidence indicates that lncRNAs (long noncoding RNAs) are critical regulators of fundamental cellular processes in a variety of tumors including breast cancer. The functional details of these regulatory elements, however, remain largely unexplored.MethodsIn this study, lncRNA ROR (linc-ROR) was examined by real-time PCR in different breast cancer cell lines and breast tumor tissues/non-tumor tissues were collected from both breast cancer patients and healthy controls. Linc-ROR was knockdown in breast cancer cell lines and the effects on cell proliferation, migration and invasion were tested both in vitro and in vivo tumor model. Effects of linc-ROR knockdown on TGF-β signaling pathway were investigated by Western blot.ResultsOur studies have suggested that linc-ROR, a critical factor for embryonic stem cell maintenance, probably acts as an oncogenic factor in breast cancer cells, causing poor prognostic outcomes. Overexpression of linc-ROR seems to be responsible for promoting proliferation and invasion of cancer cells as well as tumor growth in nude mice. The regulatory action of linc-ROR can affect the activity of the TGF-β signaling pathway, which has been proven critical for mammary development and breast cancer.ConclusionsThe results have highlighted the potential importance of linc-ROR in the progression of advanced breast cancer, and thus will stimulate efforts in the development of novel diagnostic and therapeutic strategies.