Long noncoding RNA ROR promotes breast cancer by regulating the TGF-β pathway

Hou, Lingli; Tu, Jiancheng; Cheng, Fangxiong; Yang, Hongwei; Yu, Fei; Wang, Minghua; Liu, Jiubo; Fan, Jinbo; Zhou, Gengui

doi:10.1186/s12935-018-0638-4

Cited by 49 publications

(44 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The lncRNA ROR has been first described in iPSCs and have shown to have a role in embryonic stem cells generation [10]. In the field of BC, Hou et al firstly reported that ROR could induce epithelial-to-mesenchymal transition and contribute to BC tumorigenesis and metastasis [19], and ROR could promote BC by regulating the TGF-β pathway [20]. ROR and miR-145 were elaborated to regulate invasion in triple-negative BC via targeting ARF6 [11].…”

Section: Discussionmentioning

confidence: 99%

Long non-coding RNA ROR accelerates the progression of breast cancer via promoting stemness in MCF-10A cells

S.Wang¹,

Chen²,

Song³

et al. 2020

EJGO

View full text Add to dashboard Cite

Long non-coding RNA (lncRNA), regulator of reprogramming (ROR) is an intergenic lncRNA previously shown to contribute to tumorigenesis in several malignancies. In their previous study, the present authors found that ROR was highly associated with gastric cancer progression, however, the role of ROR in breast cancer (BC) was still unclear. Here, the authors investigated the role and mechanism of ROR in BC. They found that the expression of ROR was increased in the MCF-7 cells and MDA-MB-231 cells compared with the control MCF-10A. The exogenous expression of ROR was increased using plasmid overexpressing ROR in MCF-10A cells, then the biological function of ROR was determined using MTT assay and Transwell assay. The result indicated that overexpression of ROR could significantly increase the capability of cell proliferation and invasion. Furthermore, the molecular markers for BC stem cell (BCSC) were verified, the results showed that enhanced expression of cluster of differentiation 44 (CD44) and aldehyde dehydrogenase 1 (ALDH1) was observed in MCF-10A cells with ROR overexpression. In summary, this study will further expand our understanding of ROR and provide a new target for the treatment of BC.

show abstract

Section: Discussionmentioning

confidence: 99%

Long non-coding RNA ROR accelerates the progression of breast cancer via promoting stemness in MCF-10A cells

S.Wang¹,

Chen²,

Song³

et al. 2020

EJGO

View full text Add to dashboard Cite

show abstract

“…In addition, the wound-healing assay showed that overexpression of linc-ROR increased BC cells (MCF10A) mobility. Transwell assay revealed that linc-ROR overexpression remarkably increased the migration ability (Hou et al, 2018). More importantly, they found that ectopic expression of linc-ROR induced an EMT program in MCF10A cells.…”

Section: Breast Cancermentioning

confidence: 97%

“…Hou et al investigated the expression level of linc-ROR in 94 patients (Hou et al, 2018). Their results revealed that the level of linc-ROR was increased in BC tissues.…”

Section: Breast Cancermentioning

confidence: 99%

“…Mechanistically, the results of bioinformatic analysis and RNA immunoprecipitation analysis from Hou et al demonstrated that linc-ROR functions as a ceRNA to regulate miR-205 activity toward prevention of the degradation of transcripts of miR-205 target genes, such as ZEB1 and ZEB2, from degradation. Additionally, it was shown that the expression levels of miR-205 members were decreased upon linc-ROR overexpression in MCF10A cells (Hou et al, 2018). More importantly, Zhao et al recently demonstrated that CRISPR/Cas9-generated BRCA1-knockdown adipose-derived stem cells stimulated a more aggressive behavior in BC cells than wild-type adipose-derived stem cells (Zhao et al, 2019).…”

Section: Breast Cancermentioning

confidence: 99%

See 1 more Smart Citation

Relevance Function of Linc-ROR in the Pathogenesis of Cancer

Chen

Yang

Fang

et al. 2020

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Long non-coding RNAs (lncRNAs) are the key components of non-coding RNAs (ncRNAs) with a length of 200 nucleotides. They are transcribed from the so-called "dark matter" of the genome. Increasing evidence have shown that lncRNAs play an important role in the pathophysiology of human diseases, particularly in the development and progression of tumors. Linc-ROR, as a new intergenic non-protein coding RNA, has been considered to be a pivotal regulatory factor that affects the occurrence and development of human tumors, including breast cancer (BC), colorectal cancer (CRC), pancreatic cancer (PC), hepatocellular carcinoma (HCC), and so on. Dysregulation of Linc-ROR has been closely related to advanced clinicopathological factors predicting a poor prognosis. Because linc-ROR can regulate cell proliferation, apoptosis, migration, and invasion, it can thus be used as a potential biomarker for patients with tumors and has potential clinical significance as a therapeutic target. This article reviewed the role of linc-ROR in the development of tumors, its related molecular mechanisms, and clinical values.

show abstract

“…As a ceRNA of mir-145, ROR functions via loss of mature miR-141 expression leading to the protection of pluripotency factors [213]. In BC cells and in patient samples, lncRNA ROR was not only linked to the self-renewal of stem cells, EMT transition, and drug resistance but also to poor prognosis indicating its significance in tumorigenesis process [215][216][217][218][219][220]. Mainly, lnc-ROR functions via targeting of ZEB1/2 and TGF-β signaling leading to modulation of EMT markers such as vimentin and neural (N)-cadherin and induction of EMT process [218,219,221,222].…”

Section: Role Of Micrornas and Lncrna In Bcscsmentioning

confidence: 99%

Non-Coding RNAs as Regulators and Markers for Targeting of Breast Cancer and Cancer Stem Cells

Prabhu

Raza

Karedath

et al. 2020

Cancers

View full text Add to dashboard Cite

Breast cancer is regarded as a heterogeneous and complicated disease that remains the prime focus in the domain of public health concern. Next-generation sequencing technologies provided a new perspective dimension to non-coding RNAs, which were initially considered to be transcriptional noise or a product generated from erroneous transcription. Even though understanding of biological and molecular functions of noncoding RNA remains enigmatic, researchers have established the pivotal role of these RNAs in governing a plethora of biological phenomena that includes cancer-associated cellular processes such as proliferation, invasion, migration, apoptosis, and stemness. In addition to this, the transmission of microRNAs and long non-coding RNAs was identified as a source of communication to breast cancer cells either locally or systemically. The present review provides in-depth information with an aim at discovering the fundamental potential of non-coding RNAs, by providing knowledge of biogenesis and functional roles of micro RNA and long non-coding RNAs in breast cancer and breast cancer stem cells, as either oncogenic drivers or tumor suppressors. Furthermore, non-coding RNAs and their potential role as diagnostic and therapeutic moieties have also been summarized.

show abstract

Long noncoding RNA ROR promotes breast cancer by regulating the TGF-β pathway

Cited by 49 publications

References 23 publications

Long non-coding RNA ROR accelerates the progression of breast cancer via promoting stemness in MCF-10A cells

Long non-coding RNA ROR accelerates the progression of breast cancer via promoting stemness in MCF-10A cells

Relevance Function of Linc-ROR in the Pathogenesis of Cancer

Non-Coding RNAs as Regulators and Markers for Targeting of Breast Cancer and Cancer Stem Cells

Contact Info

Product

Resources

About