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A 70-year-old womanwith small-cell lung carcinoma (c-T4N2M0) was treated by six courses of combination chemotherapy (carboplatin and etoposide). After two weeks, she complained of a sense of darkness and night blindness. A Western blot analysis showedthat the patient's serum bound with the recombinant 23-kDa retinal cancer-associated retinopathy (CAR) antigen at 1 : 1,000 dilution. Her visual acuity becameso poor that she could only recognise a hand motion at 50 cm despite treatment with corticosteroids and combination chemotherapy. The patient was diagnosed as having a rare type of CARbecause CARis usually found before the diagnosis of primary cancer. (Internal Medicine 38: 597-601, 1999)

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