Introduction Chitosan (CS) is one of the most readily available biopolymer due to preparing it from alkaline N-deacetylation of Chitin, which is the most plentiful polysaccharide in nature. The structure of chitosan is a linear co-biopolymer of 2-acetamido-2-deoxy-β-Dglucopyranose(GluNHAc) with2-amino-2-deoxy-β-D-glycopyranose (GluNH 2) (Rinaudo, M., 2006).Due to the unique properties of chitosan such as a biocompatibility, biodegradability and also its antimicrobial and anti-cancer activity (Choi et al., 2001,Chung et al., 2012,Foster et al., 2015,Xia et al., 2011),CS is very attractive for many applications in the pharmaceutical, agricultural, food, textiles and medical fields and cosmetic industries and a treatment for waste water (Crini, G., 2006, Khor et al., 2003, Miretzky et al., 2009). Moreover, many studies have shown that the modification of chitosan via Schiff bases condensation between primary amines and aldehydes increases its biological activity.
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