Tetrabutylphosphonium-salicyl-imine-chitosan metallo-Schiff bases:Supramolecular architectures as multifunctional pharmacological materials.

Abstract

Introduction Chitosan (CS) is one of the most readily available biopolymer due to preparing it from alkaline N-deacetylation of Chitin, which is the most plentiful polysaccharide in nature. The structure of chitosan is a linear co-biopolymer of 2-acetamido-2-deoxy-β-Dglucopyranose(GluNHAc) with2-amino-2-deoxy-β-D-glycopyranose (GluNH 2) (Rinaudo, M., 2006).Due to the unique properties of chitosan such as a biocompatibility, biodegradability and also its antimicrobial and anti-cancer activity (Choi et al., 2001,Chung et al., 2012,Foster et al., 2015,Xia et al., 2011),CS is very attractive for many applications in the pharmaceutical, agricultural, food, textiles and medical fields and cosmetic industries and a treatment for waste water (Crini, G., 2006, Khor et al., 2003, Miretzky et al., 2009). Moreover, many studies have shown that the modification of chitosan via Schiff bases condensation between primary amines and aldehydes increases its biological activity.

Synthesis, anticancer, anti‐inflammatory, antimicrobial activities, molecular docking, and Density functional theory studies of nanometal (IV) glycoconjugates

“…NMR observations in DMSO-d 6 as solvent: The 1 H-NMR spectrum of un-complexed ligand (H 2 L) noticed highly de-shielded singlet at a low-field region δ = 8.66 ppm referred to the proton of the azomethine (H C N) fragment, in conformity with the reported values of δ = 8.72 ppm in earlier investigations by Gelan, 66 confirming the successful formation of the desired ligand. The hydroxyl proton was observed at lowfield shift δ = 13.40 ppm, in agreement with the reported values of δ = 13.36 ppm in earlier investigations by Chang-Jian et al 67 and further compared work 68 that confirmed the strong hydrogen bond between the imino nitrogen and the hydroxyl function on the aromatic ring.…”

“…63 Hence, it supports the suggested composition of Sn (ph) 2 (HL) 2 complex under discussion. Meanwhile, the 13 C-NMR spectrum of ligand (H 2 L) provides more proof for its successful manufacturing, as prompted by observations of peaks; a lower field 13 C-NMR signals set (δ = 116-162.34, $166.97, and $61-95 ppm) characteristic for the aromatic ring carbons, azomethine and carbon skeleton of D-glucosamine segments, 59,66 respectively, that shifted to (δ = 108-143, $157.04, and $53-93 ppm) upon complexation respectively. The chemical shifts of 1 H and 13 C-NMR are listed and assigned in (Tables 3 and 4) and exhibited in (Figures S4 and S5).…”

New modified chitosan composites and nanocomposites for different applications

“…Chitosan and its nanocomposite derivatives are used in a many field that interested in the life sciences and technology such as biomedical and pharmaceutical applications [29]. Moreover, many studies have shown that the modification of chitosan via Schiff bases condensation to enhance its biological activity [30].…”