Background
Conscious sedation is a technique of providing analgesia, sedation and anxiolysis while ensuring rapid recovery without side effects. Conscious sedation is administered with the dual goals of rapidly and safely establishing satisfactory procedural condition for the performance of therapeutic or diagnostic procedures while ensuring rapid, predictable recovery with minimal post-operative sequels. Dexmedetomidine is a highly selective alpha-2 agonist that provides anxiolysis and cooperative sedation without respiratory depression. it inhibits the release of norepinephrine via actions on the alpha2A (α-2A) adrenoceptors located in the locus ceruleus and the spinal cord, resulting in sedation and analgesia via sympatholysis.
Objective
It was to study the effect of dexemdetornidine with fentanyl versus ketamine with fentanyl on hemodynamic stability and recovery during conscious sedation in dilatation and curettage procedure. The comparison included the vital data and recovery time. The effect of the drugs on hemodynamics and monitoring the occurrence of any complication were also done.
Patients and Methods
In our study, 50 patients were randomly divided into 2 equal groups; group DF received dexmedtomidine loading dose 1 πg/kg over 10 min and followed by 0.5 πg/kg/hr infusion till completion of surgery and group KF received ketamine 0.5 mg/kg slow intravenous Bolus.
Results
Dexmedetomidine is a safe drug with good hemodynamic and recovery time, also exerts sedative and analgesic effects without respiratory depression, unlike most analgesic/sedative drugs, such as ketamine, opioids, benzodiazepines and propofol.
Conclusion
This study demonstrates that dexrnedetomidine is a safe drug with good hemodynamic and recovery profile. Dexmedetomidine better preserved MBP and SpO2.
Background: Perioperative cardiac complications are an important concern for the millions of individuals who undergo surgery worldwide every year. After surgery, 2% of these patients suffer major cardiac complications.
Aim of the Work:To study the effects of perioperatively administered beta-blockers for prevention of surgery-related mortality and morbidity in patients undergoing major abdominal surgery while under general anesthesia.Patients and Methods: This is an observational prospective study, in which 240 patients were divided into 2 groups (120 patients each) as follows: Beta blocker group (BB group) 120 patients on beta blocker (Bisoprolol 5 mg) started more than 15 days preoperative and continued for at least 7 days postoperative. Control group: 120 patients not receiving any beta blocker.Results: In this study, results showed no difference between 2 groups regarding cerebrovascular events and heart failure. Equal cases of mortality happened to patients in both groups. As regards hypothension with SBP<90 mmHg, we found that it occurred to 32 patients representing 26.7 % of beta blocker group, compared to 18 patients representing 15 % of the control group.
Conclusion:Analysis of the results concluded that Patients on beta blocker are at less risk of perioperative arrhythmias and myocardial infarction when undergoing high risk surgeries. These patients are at higher risk of experiencing episodes of bradycardia and hypotension. No significant effect on perioperative heart failure, cerebrovascular stroke and mortality.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.