Objective:
Acute Myeloid Leukemia (AML) and Acute Lymphoblastic Leukemia (ALL) are clinically and biologically diverse phenotypic diseases amongst hematological malignancies. The current study objectives were to diagnose and classify cases of AL as per revised 4th edition of WHO 2016 classification of AL’s and study their clinicopathological profiles.
Material and Method:
This cross-sectional, observational study included 68 patients, diagnosed with AL were recruited. Diagnosis was based on peripheral blood smear examination, bone marrow aspiration, flowcytometry, and cytogenetic and molecular studies.
Results:
Sixty-eight cases of AL were diagnosed in a period of 2 years, where 25 cases were of ALL and 43 cases were of AML. In the subclassification of AML as per WHO 2016, 20 cases were of AML, RGA, 21 cases were of AML, NOS, and 2 cases were of AML, MRC. In AML, RGA, APL with PML-RARA positive cases were 10 out of 20 cases, AML with (8;21) RUNX1-RUNX1T1 were 7/20 cases; there were two cases of AML with mutated NPM1 gene and one case of AML with biallelic mutation of CEBPA. In AML, NOS subcategory AML with maturation was more common with 9/21cases. In subcategory of ALL, B-ALL was more common than T-ALL. B-ALL, NOS was more common than B-ALL, RGA and we had 1 case of NK cell Leukemia.
Conclusion:
The application of revised 4th edition WHO 2016 classification confers uniformity in reporting acute leukemia cases that aids in the treatment by using targeted therapies and helps in the prediction of prognosis. The WHO classification for acute leukemias is very objective, therapy oriented and the need of the hour.
In patients suffering from malignancies incidence of tuberculosis is highest in cases of hematological malignancies in comparison to solid organ malignancies. Despite the fact tuberculosis remains under-diagnosed condition in hematological malignancies like acute leukemia and it may be a cause of febrile neutropenia in these cases. Rescheduling and/or alterations in therapies are required in these cases. A 16year old male diagnosed as case of AML with t(8;21)(q22;q22.1);RUNX1-RUNX1T1 was on therapy after 6 weeks interval from initiation of therapy he presented with fever, weakness, lymphadenopathy and cough with expectoration since 15 days.
Leiomyoma is a benign tumour composed of smooth muscle cells with fibrous stroma and it is the commonest tumour amongst the tumours of uterus. As per FIGO classification system parasitic leiomyoma has no myometrial involvement or uterine attachment. These myomas get detached from the uterus and receive the blood supply from another source. The etiology and pathologic basis of these parasitic fibroids is not yet clearly understood. We report a rare case of parasitic myoma in a 29 years old female patient presented with abdominal discomfort and difficulty in micturition. Clinical examination and subsequent imaging studies revealed a pelvic mass. Histopathological examination of which proved it to be a parasitic myoma. Parasitic myoma is a rare entity which may be iatrogenically created after surgery particularly with morcellation technique. With increasing rates of laparoscopic procedures, surgeons should be aware of the possibility of formation of parasitic myoma and should take intraoperative precautions to minimise its formation.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.