<p>Molnupiravir (MK-4482) is an investigational
direct-acting antiviral agent that is under development for the
treatment of COVID-19. Given the potential high demand for this
compound, it was critical to develop a sustainable and efficient
synthesis from commodity raw materials. The three-step route that
we report here embodies the shortest possible synthesis to
molnupiravir, and was enabled through the invention of a novel
biocatalytic cascade and final condensation step. Each step occurs
in over 95% yield and only utilizes widely available commodity
reagents and simple operations. Compared to the initial route, the
new route is 70% shorter, and approximately seven-fold higher in
overall yield. <br></p>
Given recent large-scale reform of school leadership and management policy with implications for leadership preparation, the Republic of Ireland is an interesting context in which to explore leadership preparation. Although policy reforms have influenced the preparation and development of school leaders at all levels in the system, there is little available research on principals’ perceptions of their preparation to lead schools in the contemporary policy context. Addressing this gap in the research, in this study 12 recently appointed, novice primary and post-primary principals’ perceptions of their preparation to become a school leader and the reformed policy context are documented and analysed. Thematic analysis of principals’ accounts exposes a range of dualities they must navigate owing to recent reforms. Their accounts also paint their diverse pathways towards the principalship, illuminate challenges and complexities on this pathway and in their current position. Their perspectives inform a more dynamic framework of leadership preparation than that of the leadership pipeline, a common metaphor in leadership preparation, with relevance for many actors in the system, including policy-makers, researchers, practitioners and those involved in selection and appointment. Implications are drawn for the Irish context but may also be relevant to other jurisdictions considering or implementing reform of school leadership preparation.
Purpose
The purpose of this paper is to review and generate themes evident in research on primary and post-primary (secondary) school leadership in the Republic of Ireland (Ireland) from 2008 to 2018.
Design/methodology/approach
This paper follows the steps of a systematic review and thematic synthesis.
Findings
Following the review, six themes are identified and described, summarising the most current school leadership research in Ireland.
Practical implications
Potential future directions of research are identified.
Originality/value
No review of research on school leadership in Ireland is currently available and this is timely given the policy context’s recent focus on school leadership. The steps taken to conduct the review are clearly outlined.
This Article attempts to quantify the macroeconomic impact of Brexit on the Irish economy. Given both the political and economic uncertainty, we consider a range of alternative scenarios. We focus on the most well understood channels through which Brexit will affect Ireland, namely though lower trade, incorporating the impact of tariff and non-tariff measures, and the potentially positive impact of FDI diversion to Ireland. Our approach, and the main contribution of this paper, is to build up estimates of each of these channels from a range of recent microeconomic studies, so our estimates are anchored in the empirical literature. We then use these micro-estimates to calibrate macro scenarios; specifically we generate alternative paths for the UK and international economy using the NiGEM global model and assess the impact on Ireland using the COSMO model. Overall, in each scenario, the level of Irish output is permanently below where it otherwise would have been were the UK to decide to remain in the EU.
This paper examines the effect of human capital on the growth of ICT-intensive industries using data from a sample of open economies over the period 1980-1999. Our econometric analysis suggest that value added and employment in ICT-intensive industries grew relatively faster in countries with a higher ex-ante human capital stock and in countries with a fast improvement in human capital. Further, in countries with fast human capital accumulation, labour productivity in ICT-intensive industries grew faster. Our results are robust to controls for other determinants of industry growth and country characteristics affecting industry specialisation and to using alternative human capital measures.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.